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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F10%3A00056962%21RIV12-MZ0-14110___
rdf:type
skos:Concept n14:Vysledek
dcterms:description
Prognosis for children with relapsed medulloblastoma remains poor. Metronomic chemotherapy may offer some benefit to patients treated initially with intensive regimens. However, dosing and duration of such palliative treatment have not been systematically studied. Here we describe a child with medulloblastoma relapsing after initial high-dose chemotherapy and standard radiotherapy. The patient was then treated with metronomic chemotherapy and achieved second complete remission after 21 months of treatment. Three months off therapy he relapsed again and died from progressive disease. This case illustrates the potential benefit of metronomic chemotherapy but also shows the uncertainty of when to stop metronomic chemotherapy while balancing toxicity. Prognosis for children with relapsed medulloblastoma remains poor. Metronomic chemotherapy may offer some benefit to patients treated initially with intensive regimens. However, dosing and duration of such palliative treatment have not been systematically studied. Here we describe a child with medulloblastoma relapsing after initial high-dose chemotherapy and standard radiotherapy. The patient was then treated with metronomic chemotherapy and achieved second complete remission after 21 months of treatment. Three months off therapy he relapsed again and died from progressive disease. This case illustrates the potential benefit of metronomic chemotherapy but also shows the uncertainty of when to stop metronomic chemotherapy while balancing toxicity.
dcterms:title
Second complete remission of relapsed medulloblastoma induced by metronomic chemotherapy. Second complete remission of relapsed medulloblastoma induced by metronomic chemotherapy.
skos:prefLabel
Second complete remission of relapsed medulloblastoma induced by metronomic chemotherapy. Second complete remission of relapsed medulloblastoma induced by metronomic chemotherapy.
skos:notation
RIV/00216224:14110/10:00056962!RIV12-MZ0-14110___
n3:aktivita
n10:Z n10:P
n3:aktivity
P(NR9341), P(NS9873), Z(MZ0MOU2005)
n3:cisloPeriodika
4
n3:dodaniDat
n11:2012
n3:domaciTvurceVysledku
n8:7325002 n8:1398954 n8:3178730 n8:2486725 n8:4580079 n8:8551391 n8:6595596 n8:8200629
n3:druhVysledku
n18:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
286620
n3:idVysledku
RIV/00216224:14110/10:00056962
n3:jazykVysledku
n19:eng
n3:klicovaSlova
metronomic chemotherapy; relapsed medulloblastoma
n3:klicoveSlovo
n17:relapsed%20medulloblastoma n17:metronomic%20chemotherapy
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[EB5D44E39BF4]
n3:nazevZdroje
Pediatric Blood Cancer
n3:obor
n9:FD
n3:pocetDomacichTvurcuVysledku
8
n3:pocetTvurcuVysledku
9
n3:projekt
n7:NR9341 n7:NS9873
n3:rokUplatneniVysledku
n11:2010
n3:svazekPeriodika
54
n3:tvurceVysledku
Zapletalová, Danica Bajčiová, Viera Štěrba, Jaroslav Pavelka, Zdeněk Ventruba, Jiří Dubská, Lenka André, Nicolas Skotáková, Jarmila Valík, Dalibor
n3:wos
000275038900024
n3:zamer
n15:MZ0MOU2005
s:issn
1545-5009
s:numberOfPages
2
n16:doi
10.1002/pbc.22382
n5:organizacniJednotka
14110