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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F10%3A00051816%21RIV12-MSM-14110___
rdf:type
skos:Concept n16:Vysledek
dcterms:description
Checkpoint kinase 2 gene (CHEK2) alterations increase risk of several cancer types. We analyzed selected CHEK2 alterations in 270 Czech pancreatic cancer patients and in 683 healthy controls. The pancreatic cancer risk was higher in individuals who inherited rare alterations in CHEK2 region involving forkhead-associated domain other than I157T (OR = 5.14; 95% Cl = 0.94-28.23) but the observed association was non-significant (p = 0.057). The most frequent I157T mutation did not alter the pancreatic cancer risk and neither the followed deletion of 5395 bp nor c.1100delC were found in any of pancreatic cases. We conclude that the I157T, other alterations in its proximity, del5395 and c.1100delC in CHEK2 do not predispose to pancreatic cancer risk in the Czech population. Checkpoint kinase 2 gene (CHEK2) alterations increase risk of several cancer types. We analyzed selected CHEK2 alterations in 270 Czech pancreatic cancer patients and in 683 healthy controls. The pancreatic cancer risk was higher in individuals who inherited rare alterations in CHEK2 region involving forkhead-associated domain other than I157T (OR = 5.14; 95% Cl = 0.94-28.23) but the observed association was non-significant (p = 0.057). The most frequent I157T mutation did not alter the pancreatic cancer risk and neither the followed deletion of 5395 bp nor c.1100delC were found in any of pancreatic cases. We conclude that the I157T, other alterations in its proximity, del5395 and c.1100delC in CHEK2 do not predispose to pancreatic cancer risk in the Czech population.
dcterms:title
CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify risk of sporadic pancreatic cancer CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify risk of sporadic pancreatic cancer
skos:prefLabel
CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify risk of sporadic pancreatic cancer CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify risk of sporadic pancreatic cancer
skos:notation
RIV/00216224:14110/10:00051816!RIV12-MSM-14110___
n3:aktivita
n6:Z n6:I n6:P
n3:aktivity
I, P(NS9799), Z(MSM0021620808), Z(MZ0MOU2005)
n3:cisloPeriodika
5
n3:dodaniDat
n5:2012
n3:domaciTvurceVysledku
n18:1030779
n3:druhVysledku
n11:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
250536
n3:idVysledku
RIV/00216224:14110/10:00051816
n3:jazykVysledku
n13:eng
n3:klicovaSlova
Checkpoint kinase 2; Alterations; Deletion; Pancreatic cancer; Risk
n3:klicoveSlovo
n4:Risk n4:Alterations n4:Checkpoint%20kinase%202 n4:Pancreatic%20cancer n4:Deletion
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[A86D7AADBA5F]
n3:nazevZdroje
Cancer epidemiology
n3:obor
n20:FD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
7
n3:projekt
n10:NS9799
n3:rokUplatneniVysledku
n5:2010
n3:svazekPeriodika
34
n3:tvurceVysledku
Havránek, O. Mohelníková-Duchoňová, B. Souček, Pavel Pohlreich, Petr Kleibl, Zdeněk Foretová, Lenka Hlavata, I.
n3:wos
000283974700024
n3:zamer
n17:MZ0MOU2005 n17:MSM0021620808
s:issn
1877-7821
s:numberOfPages
3
n14:doi
10.1016/j.canep.2010.06.008
n12:organizacniJednotka
14110