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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F10%3A00051747%21RIV12-MSM-14110___
rdf:type
n8:Vysledek skos:Concept
dcterms:description
A mathematical model of human ventricular cell incorporating the transverse axial tubular system (TATS) was designed and used to explore the role of TATS in human ventricular cell electrophysiological activity. The model is based on the latest quantitative description of guinea pig ventricular cell electrophysiology and modified to respect the published data obtained from human cardiac preparations. Computer simulations suggest that significant transient depletions of Ca2+ ions and accumulation of K+ ions may occur in the human TATS. The preliminary analysis of the effects of tubular Ca2+depletions on the activity of the model cell indicates their role in limitation of intracellular Ca2+ overload at higher frequencies of stimulation. A mathematical model of human ventricular cell incorporating the transverse axial tubular system (TATS) was designed and used to explore the role of TATS in human ventricular cell electrophysiological activity. The model is based on the latest quantitative description of guinea pig ventricular cell electrophysiology and modified to respect the published data obtained from human cardiac preparations. Computer simulations suggest that significant transient depletions of Ca2+ ions and accumulation of K+ ions may occur in the human TATS. The preliminary analysis of the effects of tubular Ca2+depletions on the activity of the model cell indicates their role in limitation of intracellular Ca2+ overload at higher frequencies of stimulation.
dcterms:title
Physiological consequences of ion concentration changes in transverse-axial tubular system in a model of human ventricular cardiomyocyte Physiological consequences of ion concentration changes in transverse-axial tubular system in a model of human ventricular cardiomyocyte
skos:prefLabel
Physiological consequences of ion concentration changes in transverse-axial tubular system in a model of human ventricular cardiomyocyte Physiological consequences of ion concentration changes in transverse-axial tubular system in a model of human ventricular cardiomyocyte
skos:notation
RIV/00216224:14110/10:00051747!RIV12-MSM-14110___
n3:aktivita
n14:Z
n3:aktivity
Z(MSM0021622402)
n3:cisloPeriodika
1
n3:dodaniDat
n12:2012
n3:domaciTvurceVysledku
n13:7773625
n3:druhVysledku
n7:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
278935
n3:idVysledku
RIV/00216224:14110/10:00051747
n3:jazykVysledku
n18:eng
n3:klicovaSlova
cardiac cell; transverse-axial tubular system; quantitative model
n3:klicoveSlovo
n5:cardiac%20cell n5:quantitative%20model n5:transverse-axial%20tubular%20system
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[F0994A1826C9]
n3:nazevZdroje
Analysis of Biomedical Signals and Images
n3:obor
n11:BO
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n12:2010
n3:svazekPeriodika
20
n3:tvurceVysledku
Pásek, Michal Ohlídalová, Dana Christé, Georges Šimurda, Jiří
n3:zamer
n17:MSM0021622402
s:issn
1211-412X
s:numberOfPages
4
n9:organizacniJednotka
14110