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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F10%3A00051729%21RIV12-MSM-14110___
rdf:type
n9:Vysledek skos:Concept
dcterms:description
During the progression of sepsis from early hit to multiorgan failure proinflammatory and anti-inflammatory cytokines are released. Cytokines can be used as biomarkers to determine the specific patterns of sepsis progression and association with mortality. In our study CRP levels correlated with the probability of survival, following levels of TREM-1, PCT and IL-6. Contrary to CRP and PCT levels, which rapidly fell during the first study days, levels of cytokines and TREM-I remained elevated throughout the study period, but were not so high and even normal in these subjects with severe sepsis despite early enrolment. Severity of disease at presentation correlated with levels of CRP, PCT, TREM-1, IL-6, IL-12, IL-4, IL-1 beta and TNF, especially in children. Response of circulating cytokines in patients with severe sepsis is heterogeneous in adults and children population and there is a specific pattern of this response related to mortality and severity at presentation. During the progression of sepsis from early hit to multiorgan failure proinflammatory and anti-inflammatory cytokines are released. Cytokines can be used as biomarkers to determine the specific patterns of sepsis progression and association with mortality. In our study CRP levels correlated with the probability of survival, following levels of TREM-1, PCT and IL-6. Contrary to CRP and PCT levels, which rapidly fell during the first study days, levels of cytokines and TREM-I remained elevated throughout the study period, but were not so high and even normal in these subjects with severe sepsis despite early enrolment. Severity of disease at presentation correlated with levels of CRP, PCT, TREM-1, IL-6, IL-12, IL-4, IL-1 beta and TNF, especially in children. Response of circulating cytokines in patients with severe sepsis is heterogeneous in adults and children population and there is a specific pattern of this response related to mortality and severity at presentation.
dcterms:title
Cytokine response in severe sepsis - predicting the course of illness in adult and paediatric patients Cytokine response in severe sepsis - predicting the course of illness in adult and paediatric patients
skos:prefLabel
Cytokine response in severe sepsis - predicting the course of illness in adult and paediatric patients Cytokine response in severe sepsis - predicting the course of illness in adult and paediatric patients
skos:notation
RIV/00216224:14110/10:00051729!RIV12-MSM-14110___
n4:aktivita
n7:I
n4:aktivity
I
n4:dodaniDat
n11:2012
n4:domaciTvurceVysledku
n10:2985462 n10:7753241 n10:5734665 n10:3060632 n10:6522319 n10:1852698 n10:6069339 n10:4382498 n10:5060389 n10:4149734
n4:druhVysledku
n18:D
n4:duvernostUdaju
n13:S
n4:entitaPredkladatele
n14:predkladatel
n4:idSjednocenehoVysledku
252649
n4:idVysledku
RIV/00216224:14110/10:00051729
n4:jazykVysledku
n17:eng
n4:klicovaSlova
sepsis; multiorgan failure; Cytokines; CRP; PCT; TREM-1; IL-6; IL-12; IL-4; IL-1 beta; TNF
n4:klicoveSlovo
n5:TNF n5:CRP n5:IL-6 n5:IL-1%20beta n5:TREM-1 n5:sepsis n5:PCT n5:Cytokines n5:IL-4 n5:IL-12 n5:multiorgan%20failure
n4:kontrolniKodProRIV
[01D81DFDF2F3]
n4:mistoKonaniAkce
Munich, Germany
n4:mistoVydani
Philadelphia
n4:nazevZdroje
Proceedings of the 8th World Congress on Trauma, Shock, Inflammation and Sepsis, Selected Papers
n4:obor
n19:FN
n4:pocetDomacichTvurcuVysledku
10
n4:pocetTvurcuVysledku
10
n4:rokUplatneniVysledku
n11:2010
n4:tvurceVysledku
Michálek, Jaroslav Fedora, Michal Jabandžiev, Petr Muriová, Katarína Šrámek, Vladimír Kratochvíl, Milan Ševčík, Pavel Kýr, Michal Otevřel, Filip Maláska, Jan
n4:typAkce
n15:WRD
n4:wos
000281967800007
n4:zahajeniAkce
2010-03-09+01:00
s:numberOfPages
5
n16:hasPublisher
Thomson Reuters
n3:isbn
978-88-6521-024-6
n6:organizacniJednotka
14110