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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F10%3A00051512%21RIV12-MSM-14110___
rdf:type
n7:Vysledek skos:Concept
dcterms:description
Ethanol reversibly decelerated the upstroke velocity and decreased AP amplitude and duration at 0.2 and 3 Hz. The fast sodium current INa, L-type calcium current ICa and transient outward potassium current Ito were reversibly inhibited in a concentration-dependent manner.As a consequence of marked differences in nH, sensitivity of the currents to ethanol at 10%-inhibition decreases in the following order: ICa (75 mM, 3.5 promile), Ito (170 mM, 7.8 promile) and INa (220 mM, 10.1 promile). Ethanol reversibly decelerated the upstroke velocity and decreased AP amplitude and duration at 0.2 and 3 Hz. The fast sodium current INa, L-type calcium current ICa and transient outward potassium current Ito were reversibly inhibited in a concentration-dependent manner.As a consequence of marked differences in nH, sensitivity of the currents to ethanol at 10%-inhibition decreases in the following order: ICa (75 mM, 3.5 promile), Ito (170 mM, 7.8 promile) and INa (220 mM, 10.1 promile).
dcterms:title
Effect of ethanol on action potential and ionic membrane currents in rat ventricular myocytes Effect of ethanol on action potential and ionic membrane currents in rat ventricular myocytes
skos:prefLabel
Effect of ethanol on action potential and ionic membrane currents in rat ventricular myocytes Effect of ethanol on action potential and ionic membrane currents in rat ventricular myocytes
skos:notation
RIV/00216224:14110/10:00051512!RIV12-MSM-14110___
n4:aktivita
n10:Z
n4:aktivity
Z(AV0Z20760514), Z(MSM0021622402)
n4:cisloPeriodika
4
n4:dodaniDat
n16:2012
n4:domaciTvurceVysledku
n9:1457160 n9:1722026 n9:7511671 n9:8165459 n9:7773625 n9:3354237
n4:druhVysledku
n14:J
n4:duvernostUdaju
n11:S
n4:entitaPredkladatele
n17:predkladatel
n4:idSjednocenehoVysledku
255971
n4:idVysledku
RIV/00216224:14110/10:00051512
n4:jazykVysledku
n19:eng
n4:klicovaSlova
ethanol; action potential; sodium current; calcium current; transient outward potassium current; rat ventricular myocytes
n4:klicoveSlovo
n6:calcium%20current n6:transient%20outward%20potassium%20current n6:ethanol n6:action%20potential n6:rat%20ventricular%20myocytes n6:sodium%20current
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[E7FDF70E87C6]
n4:nazevZdroje
Acta Physiologica
n4:obor
n15:ED
n4:pocetDomacichTvurcuVysledku
6
n4:pocetTvurcuVysledku
7
n4:rokUplatneniVysledku
n16:2010
n4:svazekPeriodika
200
n4:tvurceVysledku
Pásek, Michal Jansová, Dagmar Bébarová, Markéta Matejovič, Peter Šimurdová, Milena Ohlídalová, Dana Šimurda, Jiří
n4:wos
000284810500002
n4:zamer
n5:MSM0021622402 n5:AV0Z20760514
s:issn
1748-1708
s:numberOfPages
14
n18:doi
10.1111/j.1748-1716.2010.02162.x
n12:organizacniJednotka
14110