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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F10%3A00051346%21RIV12-MSM-14110___
rdf:type
skos:Concept n13:Vysledek
dcterms:description
To compare the predictivity of the neuroactive steroids in the cerebrospinal fluid and peripheral blood for the diagnostics of CNS disturbances, eighteen unconjugated steroids were quantified in the cerebrospinal fluid (CSF) from the 3rd ventricle and 18 unconjugated steroids and 7 steroid polar conjugates were measured in the serum using GC-MS and RIA. Eight postmenopausal women (56-78 years of age) and 7 men (22-88 years of age) with hydrocephalus were enrolled in the study. The sensitivity of the method ranged from low femtogram to low picogram levels depending on the steroid fragmentation pattern. Using multivariate regression, a model for simultaneous prediction of the CSF steroids from the serum steroids was completed. Then, the penetrability of the individual steroids across the blood-brain-barrier was evaluated and the sources of various brain steroids were estimated. Our data show that a part of the steroids may be synthesized de novo in the CNS. To compare the predictivity of the neuroactive steroids in the cerebrospinal fluid and peripheral blood for the diagnostics of CNS disturbances, eighteen unconjugated steroids were quantified in the cerebrospinal fluid (CSF) from the 3rd ventricle and 18 unconjugated steroids and 7 steroid polar conjugates were measured in the serum using GC-MS and RIA. Eight postmenopausal women (56-78 years of age) and 7 men (22-88 years of age) with hydrocephalus were enrolled in the study. The sensitivity of the method ranged from low femtogram to low picogram levels depending on the steroid fragmentation pattern. Using multivariate regression, a model for simultaneous prediction of the CSF steroids from the serum steroids was completed. Then, the penetrability of the individual steroids across the blood-brain-barrier was evaluated and the sources of various brain steroids were estimated. Our data show that a part of the steroids may be synthesized de novo in the CNS.
dcterms:title
Peripheral neuroactive steroids may be as good as the steroids in the cerebrospinal fluid for the diagnostics of CNS disturbances Peripheral neuroactive steroids may be as good as the steroids in the cerebrospinal fluid for the diagnostics of CNS disturbances
skos:prefLabel
Peripheral neuroactive steroids may be as good as the steroids in the cerebrospinal fluid for the diagnostics of CNS disturbances Peripheral neuroactive steroids may be as good as the steroids in the cerebrospinal fluid for the diagnostics of CNS disturbances
skos:notation
RIV/00216224:14110/10:00051346!RIV12-MSM-14110___
n3:aktivita
n8:I n8:P
n3:aktivity
I, P(NR9157)
n3:cisloPeriodika
1-2
n3:dodaniDat
n18:2012
n3:domaciTvurceVysledku
n14:9418431 n14:1791656 n14:7854870
n3:druhVysledku
n17:J
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
278542
n3:idVysledku
RIV/00216224:14110/10:00051346
n3:jazykVysledku
n16:eng
n3:klicovaSlova
Steroids; Cerebrospinal fluid (CSF); Plasma; Metabolome; GC-MS
n3:klicoveSlovo
n10:Steroids n10:Metabolome n10:GC-MS n10:Plasma n10:Cerebrospinal%20fluid%20%28CSF%29
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[4E9E50E468E5]
n3:nazevZdroje
Journal of Steroid Biochemistry and Molecular Biology
n3:obor
n4:FH
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
8
n3:projekt
n7:NR9157
n3:rokUplatneniVysledku
n18:2010
n3:svazekPeriodika
119
n3:tvurceVysledku
Velikova, Marta Chrastina, Jan Kancheva, Radmila Hill, Martin Kancheva, Lyudmila Říha, Ivo Starka, Luboslav Novák, Zdeněk
n3:wos
000276259500004
s:issn
0960-0760
s:numberOfPages
10
n15:doi
10.1016/j.jsbmb.2009.12.006
n19:organizacniJednotka
14110