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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F10%3A00051339%21RIV12-MSM-14110___
rdf:type
skos:Concept n14:Vysledek
dcterms:description
The controlled in vitro differentiation of human embryonic stem cells (hESCs) and other pluripotent stem cells provides interesting prospects for generating large numbers of human neurons for a variety of biomedical applications. A major bottleneck associated with this approach is the long time required for hESC-derived neural cells to give rise to mature neuronal progeny. In the developing vertebrate nervous system, Notch signaling represents a key regulator of neural stem cell (NSC) maintenance. Here, we set out to explore whether this signaling pathway can be exploited to modulate the differentiation of hESC-derived NSCs (hESNSCs). We assessed the expression of Notch pathway components in hESNSCs and demonstrate that Notch signaling is active under self-renewing culture conditions. The controlled in vitro differentiation of human embryonic stem cells (hESCs) and other pluripotent stem cells provides interesting prospects for generating large numbers of human neurons for a variety of biomedical applications. A major bottleneck associated with this approach is the long time required for hESC-derived neural cells to give rise to mature neuronal progeny. In the developing vertebrate nervous system, Notch signaling represents a key regulator of neural stem cell (NSC) maintenance. Here, we set out to explore whether this signaling pathway can be exploited to modulate the differentiation of hESC-derived NSCs (hESNSCs). We assessed the expression of Notch pathway components in hESNSCs and demonstrate that Notch signaling is active under self-renewing culture conditions.
dcterms:title
Inhibition of Notch Signaling in Human Embryonic Stem Cell-Derived Neural Stem Cells Delays G1/S Phase Transition and Accelerates Neuronal Differentiation In Vitro and In Vivo Inhibition of Notch Signaling in Human Embryonic Stem Cell-Derived Neural Stem Cells Delays G1/S Phase Transition and Accelerates Neuronal Differentiation In Vitro and In Vivo
skos:prefLabel
Inhibition of Notch Signaling in Human Embryonic Stem Cell-Derived Neural Stem Cells Delays G1/S Phase Transition and Accelerates Neuronal Differentiation In Vitro and In Vivo Inhibition of Notch Signaling in Human Embryonic Stem Cell-Derived Neural Stem Cells Delays G1/S Phase Transition and Accelerates Neuronal Differentiation In Vitro and In Vivo
skos:notation
RIV/00216224:14110/10:00051339!RIV12-MSM-14110___
n5:aktivita
n19:Z
n5:aktivity
Z(AV0Z50390703), Z(MSM0021622430)
n5:cisloPeriodika
5
n5:dodaniDat
n12:2012
n5:domaciTvurceVysledku
n11:8064296 n11:3015459
n5:druhVysledku
n7:J
n5:duvernostUdaju
n18:S
n5:entitaPredkladatele
n17:predkladatel
n5:idSjednocenehoVysledku
264007
n5:idVysledku
RIV/00216224:14110/10:00051339
n5:jazykVysledku
n13:eng
n5:klicovaSlova
Neural stem cells; Notch; Neuron; Cell cycle
n5:klicoveSlovo
n8:Cell%20cycle n8:Neuron n8:Neural%20stem%20cells n8:Notch
n5:kodStatuVydavatele
US - Spojené státy americké
n5:kontrolniKodProRIV
[DF1BBA216571]
n5:nazevZdroje
Stem Cells
n5:obor
n9:EB
n5:pocetDomacichTvurcuVysledku
2
n5:pocetTvurcuVysledku
10
n5:rokUplatneniVysledku
n12:2010
n5:svazekPeriodika
28
n5:tvurceVysledku
Steinfarz, B. Hampl, Aleš Brüstle, O. Leinhaas, A. Koch, Petr Doležalová, Dáša Borghese, L. Edenhofer, F. Haupt, S. Opitz, T.
n5:wos
000278497400012
n5:zamer
n6:MSM0021622430 n6:AV0Z50390703
s:issn
1066-5099
s:numberOfPages
10
n15:doi
10.1002/stem.408
n16:organizacniJednotka
14110