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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F10%3A00051241%21RIV12-MSM-14110___
rdf:type
n14:Vysledek skos:Concept
dcterms:description
The role of autologous hematopoietic SCT (autoHSCT) in the treatment of high-risk (HR) adult ALL is controversial. In this study, we retrospectively analyzed the results of autoHSCT according to the status of minimal residual disease (MRD) at transplantation, as a joint analysis of the European Study Group for Adult ALL (EWALL). Data on 123 recipients of autoHSCT, aged 31 (16–59) years, with B-lineage or T-lineage ALL were included. In a cohort of Ph-negative ALL, the probability of leukemia-free survival at 5 years was higher for patients with MRD o0.1% compared with those with MRD X0.1%. The difference was significant for T-lineage ALL, and a tendency was observed for B-lineage ALL. In a multivariate analysis, adjusted for other potential prognostic factors, high MRD level remained the only independent factor associated with increased risk of failure. We conclude that MRD determines the outcome of autoHSCT in HR adult ALL. The role of autologous hematopoietic SCT (autoHSCT) in the treatment of high-risk (HR) adult ALL is controversial. In this study, we retrospectively analyzed the results of autoHSCT according to the status of minimal residual disease (MRD) at transplantation, as a joint analysis of the European Study Group for Adult ALL (EWALL). Data on 123 recipients of autoHSCT, aged 31 (16–59) years, with B-lineage or T-lineage ALL were included. In a cohort of Ph-negative ALL, the probability of leukemia-free survival at 5 years was higher for patients with MRD o0.1% compared with those with MRD X0.1%. The difference was significant for T-lineage ALL, and a tendency was observed for B-lineage ALL. In a multivariate analysis, adjusted for other potential prognostic factors, high MRD level remained the only independent factor associated with increased risk of failure. We conclude that MRD determines the outcome of autoHSCT in HR adult ALL.
dcterms:title
Status of minimal residual disease determines outcome of autologous hematopoietic SCT in adult ALL Status of minimal residual disease determines outcome of autologous hematopoietic SCT in adult ALL
skos:prefLabel
Status of minimal residual disease determines outcome of autologous hematopoietic SCT in adult ALL Status of minimal residual disease determines outcome of autologous hematopoietic SCT in adult ALL
skos:notation
RIV/00216224:14110/10:00051241!RIV12-MSM-14110___
n3:aktivita
n9:V
n3:aktivity
V
n3:cisloPeriodika
6
n3:dodaniDat
n11:2012
n3:domaciTvurceVysledku
n10:1248790 n10:4376285
n3:druhVysledku
n13:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
289992
n3:idVysledku
RIV/00216224:14110/10:00051241
n3:jazykVysledku
n15:eng
n3:klicovaSlova
auto transplant; ALL; minimal residual disease
n3:klicoveSlovo
n4:auto%20transplant n4:ALL n4:minimal%20residual%20disease
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[4F47EB718EE6]
n3:nazevZdroje
Bone Marrow Transplantation
n3:obor
n8:FD
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
15
n3:rokUplatneniVysledku
n11:2010
n3:svazekPeriodika
45
n3:tvurceVysledku
Piatkowska-Jakubas, B. Krawczyk-Kulis, M. Doubek, Michael Mayer, Jiří Ribera, J. M. Czerw, T. Gökbuget, N. Holowiecki, J. Piccaluga, P. P. Dombret, H. Kyrcz-Krzemien, S. Skotnicki, A. B. Stella-Holowiecka, B. Giebel, S. Hoelzer, D.
n3:wos
000278573600021
s:issn
0268-3369
s:numberOfPages
7
n17:doi
10.1038/bmt.2009.308
n18:organizacniJednotka
14110