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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F10%3A00046985%21RIV11-MSM-14110___
rdf:type
n16:Vysledek skos:Concept
dcterms:description
Arterial occlusion due to thrombosis caused by ruptured atherosclerotic plaques has been recognized as a major cause of morbidity and mortality in western populations. Along with chronic heart failure it significantly decreases patient life expectancy. The major goal of treatment remains fast recanalization and acute reocclusion prevention. Direct (antithrombin-independent) thrombin inhibitors can be divided into two main categories: monovalent and bivalent, while antithrombin stimulators represent standard (unfractionated) heparin (UFH) and its depolymerizing products - low molecular weight heparins (LMWH's). Recently a shift to prophylaxis of thromboembolic disease has been advocated. Unlike standard heparin, low-molecular weight heparins do not affect the patient's general coagulation profile. Obviously, the difference in molecular weight results in different pharmacokinetic and pharmacodynamic properties of the agents. Arterial occlusion due to thrombosis caused by ruptured atherosclerotic plaques has been recognized as a major cause of morbidity and mortality in western populations. Along with chronic heart failure it significantly decreases patient life expectancy. The major goal of treatment remains fast recanalization and acute reocclusion prevention. Direct (antithrombin-independent) thrombin inhibitors can be divided into two main categories: monovalent and bivalent, while antithrombin stimulators represent standard (unfractionated) heparin (UFH) and its depolymerizing products - low molecular weight heparins (LMWH's). Recently a shift to prophylaxis of thromboembolic disease has been advocated. Unlike standard heparin, low-molecular weight heparins do not affect the patient's general coagulation profile. Obviously, the difference in molecular weight results in different pharmacokinetic and pharmacodynamic properties of the agents.
dcterms:title
Heparin and its derivatives in the treatment of arterial thrombosis: a review Heparin and its derivatives in the treatment of arterial thrombosis: a review
skos:prefLabel
Heparin and its derivatives in the treatment of arterial thrombosis: a review Heparin and its derivatives in the treatment of arterial thrombosis: a review
skos:notation
RIV/00216224:14110/10:00046985!RIV11-MSM-14110___
n4:aktivita
n17:V
n4:aktivity
V
n4:cisloPeriodika
11
n4:dodaniDat
n7:2011
n4:domaciTvurceVysledku
n6:1257447 n6:3130592 n6:3221059 n6:5499755 n6:2819546 n6:7252846
n4:druhVysledku
n12:J
n4:duvernostUdaju
n14:S
n4:entitaPredkladatele
n13:predkladatel
n4:idSjednocenehoVysledku
261392
n4:idVysledku
RIV/00216224:14110/10:00046985
n4:jazykVysledku
n9:eng
n4:klicovaSlova
coagulation; arterial thrombosis; standard heparin; low-molecular weight heparins
n4:klicoveSlovo
n5:arterial%20thrombosis n5:low-molecular%20weight%20heparins n5:standard%20heparin n5:coagulation
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[E46C258D1705]
n4:nazevZdroje
Veterinární medicína
n4:obor
n11:FJ
n4:pocetDomacichTvurcuVysledku
6
n4:pocetTvurcuVysledku
7
n4:rokUplatneniVysledku
n7:2010
n4:svazekPeriodika
55
n4:tvurceVysledku
Vlašín, Michal Staffa, Robert Dvořáková, Martina Lexmaulová, Leona Gregor, Zdeněk Dvořák, Martin Raušer, Petr
n4:wos
000285646900001
s:issn
0375-8427
s:numberOfPages
24
n15:organizacniJednotka
14110