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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F10%3A00046962%21RIV11-MSM-14110___
rdf:type
n7:Vysledek skos:Concept
dcterms:description
An existing model of the rat ventricular myocyte was modified to reproduce the experimentally observed differential effects of the fast and slow exogenous Ca2+ buffers BAPTA and EGTA on inactivation of ICa and to investigate the possible cause. The results of the simulations suggest that the different potencies of EGTA and BAPTA on inactivation of ICa are due to their different rates of Ca2+ binding, and thus different intracellular gradients of bound and unbound buffer, causing different rates of diffusion of bound and unbound buffer out of and into the dyadic space. The consequent difference in suppression of the Ca2+ transient in the dyadic space caused different rates of Ca2+ - induced inactivation of ICa in the presence of the two buffers. An existing model of the rat ventricular myocyte was modified to reproduce the experimentally observed differential effects of the fast and slow exogenous Ca2+ buffers BAPTA and EGTA on inactivation of ICa and to investigate the possible cause. The results of the simulations suggest that the different potencies of EGTA and BAPTA on inactivation of ICa are due to their different rates of Ca2+ binding, and thus different intracellular gradients of bound and unbound buffer, causing different rates of diffusion of bound and unbound buffer out of and into the dyadic space. The consequent difference in suppression of the Ca2+ transient in the dyadic space caused different rates of Ca2+ - induced inactivation of ICa in the presence of the two buffers.
dcterms:title
Effect of BAPTA and EGTA on inactivation of ICa in a model of rat ventricular myocyte Effect of BAPTA and EGTA on inactivation of ICa in a model of rat ventricular myocyte
skos:prefLabel
Effect of BAPTA and EGTA on inactivation of ICa in a model of rat ventricular myocyte Effect of BAPTA and EGTA on inactivation of ICa in a model of rat ventricular myocyte
skos:notation
RIV/00216224:14110/10:00046962!RIV11-MSM-14110___
n3:aktivita
n11:Z
n3:aktivity
Z(MSM0021622402)
n3:cisloPeriodika
1
n3:dodaniDat
n8:2011
n3:domaciTvurceVysledku
n13:7773625 n13:7511671
n3:druhVysledku
n17:J
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
255887
n3:idVysledku
RIV/00216224:14110/10:00046962
n3:jazykVysledku
n18:eng
n3:klicovaSlova
cardiac cell; BAPTA; EGTA; calcium current; quantitative model
n3:klicoveSlovo
n10:EGTA n10:calcium%20current n10:BAPTA n10:cardiac%20cell n10:quantitative%20model
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[F8D7B7E50192]
n3:nazevZdroje
Analysis of Biomedical Signals and Images
n3:obor
n4:BO
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
3
n3:rokUplatneniVysledku
n8:2010
n3:svazekPeriodika
20
n3:tvurceVysledku
Pásek, Michal Orchard, Clive Šimurda, Jiří
n3:zamer
n12:MSM0021622402
s:issn
1211-412X
s:numberOfPages
4
n14:organizacniJednotka
14110