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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F10%3A00045742%21RIV11-GA0-14110___
rdf:type
skos:Concept n17:Vysledek
dcterms:description
Numerous ligands of sigma receptors are known to prolong the QT interval and therefore to cause a variety of arrhythmias. High affinity binding sites for the prototypical sigma ligand haloperidol were found in membranes of cardiac myocytes from adult rats. Activation of sigma 1 receptor leads to a release of calcium from the endoplasmic reticulum that follows increased synthesis of inositol 1,4,5-trisphosphate (IP3). We studied the effect of long-term haloperidol treatment on the expression of sigma 1 receptors, IP3 receptors of type 1 and 2 in the individual parts of the rat heart, in isolated rat cardiomyocytes and in PC12 cells. We have found that prolonged treatment with haloperidol significantly increased mRNA levels of sigma 1 receptors in both atria and ventricles. Sigma 1 receptor s mRNA was increased also in isolated cardiomyocytes. Haloperidol treatment affects the expression of IP3 receptors of type 1 and 2 in cardiac atria, but not in cardiac ventricles. Numerous ligands of sigma receptors are known to prolong the QT interval and therefore to cause a variety of arrhythmias. High affinity binding sites for the prototypical sigma ligand haloperidol were found in membranes of cardiac myocytes from adult rats. Activation of sigma 1 receptor leads to a release of calcium from the endoplasmic reticulum that follows increased synthesis of inositol 1,4,5-trisphosphate (IP3). We studied the effect of long-term haloperidol treatment on the expression of sigma 1 receptors, IP3 receptors of type 1 and 2 in the individual parts of the rat heart, in isolated rat cardiomyocytes and in PC12 cells. We have found that prolonged treatment with haloperidol significantly increased mRNA levels of sigma 1 receptors in both atria and ventricles. Sigma 1 receptor s mRNA was increased also in isolated cardiomyocytes. Haloperidol treatment affects the expression of IP3 receptors of type 1 and 2 in cardiac atria, but not in cardiac ventricles.
dcterms:title
Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles
skos:prefLabel
Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles
skos:notation
RIV/00216224:14110/10:00045742!RIV11-GA0-14110___
n3:aktivita
n16:P n16:Z
n3:aktivity
P(GA102/07/1473), Z(MSM0021622402)
n3:cisloPeriodika
4
n3:dodaniDat
n13:2011
n3:domaciTvurceVysledku
n6:5074169 n6:1469517
n3:druhVysledku
n9:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
261163
n3:idVysledku
RIV/00216224:14110/10:00045742
n3:jazykVysledku
n10:eng
n3:klicovaSlova
haloperidol; sigma receptor; IP3 receptor
n3:klicoveSlovo
n4:haloperidol n4:IP3%20receptor n4:sigma%20receptor
n3:kodStatuVydavatele
SK - Slovenská republika
n3:kontrolniKodProRIV
[0A72E3E39843]
n3:nazevZdroje
General Physioogy and Biophysics
n3:obor
n15:ED
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
5
n3:projekt
n18:GA102%2F07%2F1473
n3:rokUplatneniVysledku
n13:2010
n3:svazekPeriodika
29
n3:tvurceVysledku
Nováková, Marie Fialová, Kateřina Sedláková, Barbora Križanová, Olga Sirová, Marta
n3:zamer
n14:MSM0021622402
s:issn
0231-5882
s:numberOfPages
9
n8:organizacniJednotka
14110