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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F10%3A00043106%21RIV11-GA0-14110___
rdf:type
n17:Vysledek skos:Concept
dcterms:description
Cdk1 kinase phosphorylates budding yeast Srs2, a member of UvrD protein family that displays both DNA translocation and DNA unwinding activities in vitro. Srs2 prevents homologous recombination by dismantling Rad51 filaments and it is also required for double strand break repair. Here we examine the biological significance of Cdk1-dependent phosphorylation of Srs2 using mutants that constitutively express the phosphorylated or unphosphorylated isoforms. We found that Cdk1 targets Srs2 to repair double strand break (DSB) after strand invasion. Srs2 phosphorylation is required to complete synthesis-dependent strand annealing pathway, likely controlling the disassembly of the D-loop intermediate. Cdk1 phosphorylation, indeed, controls the turnover of Srs2 protein at the invading strand, while it is not required for that of Rad51. Cdk1 kinase phosphorylates budding yeast Srs2, a member of UvrD protein family that displays both DNA translocation and DNA unwinding activities in vitro. Srs2 prevents homologous recombination by dismantling Rad51 filaments and it is also required for double strand break repair. Here we examine the biological significance of Cdk1-dependent phosphorylation of Srs2 using mutants that constitutively express the phosphorylated or unphosphorylated isoforms. We found that Cdk1 targets Srs2 to repair double strand break (DSB) after strand invasion. Srs2 phosphorylation is required to complete synthesis-dependent strand annealing pathway, likely controlling the disassembly of the D-loop intermediate. Cdk1 phosphorylation, indeed, controls the turnover of Srs2 protein at the invading strand, while it is not required for that of Rad51.
dcterms:title
Cdk1 targets Srs2 to complete synthesis-dependent strand annealing and to promote Cdk1 targets Srs2 to complete synthesis-dependent strand annealing and to promote
skos:prefLabel
Cdk1 targets Srs2 to complete synthesis-dependent strand annealing and to promote Cdk1 targets Srs2 to complete synthesis-dependent strand annealing and to promote
skos:notation
RIV/00216224:14110/10:00043106!RIV11-GA0-14110___
n3:aktivita
n10:P n10:Z
n3:aktivity
P(GA301/09/1917), P(GD203/09/H046), P(ME10048), Z(MSM0021622413)
n3:cisloPeriodika
2
n3:dodaniDat
n14:2011
n3:domaciTvurceVysledku
n15:2565277
n3:druhVysledku
n12:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
249786
n3:idVysledku
RIV/00216224:14110/10:00043106
n3:jazykVysledku
n8:eng
n3:klicovaSlova
DNA repair; DNA damage; replication; genomic instability
n3:klicoveSlovo
n4:replication n4:DNA%20damage n4:genomic%20instability n4:DNA%20repair
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[2D42D92EEDBB]
n3:nazevZdroje
PLoS Genetics
n3:obor
n9:CE
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
7
n3:projekt
n13:GA301%2F09%2F1917 n13:ME10048 n13:GD203%2F09%2FH046
n3:rokUplatneniVysledku
n14:2010
n3:svazekPeriodika
2010
n3:tvurceVysledku
Krejčí, Lumír Giordano, Liberi Hannah, Klein Xiuzhong, Zheng James, Haber Marco, Saporano Devon, Callahan
n3:wos
000275262700009
n3:zamer
n18:MSM0021622413
s:issn
1553-7390
s:numberOfPages
8
n19:organizacniJednotka
14110