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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F10%3A00040866%21RIV11-MZ0-14110___
rdf:type
n12:Vysledek skos:Concept
dcterms:description
Zinc as an essential element plays the crucial role in many physiological, but also pathological processes - zinc controls cell proliferation, differentiation, and viability including the apoptosis. These facts are especially based on the structural role of zinc ions in many proteins including the transcription factors. Due to the role of zinc in many crucial physiological processes, its homeostasis must be intensively controlled. The controlling mechanisms are based especially on the zinc transporters and low-molecular proteins metallothioneins (MTs) of the molecular weight between 6 and 10 kDa, which were firstly discovered in a horse kidneys as the cadmium binding protein. High affinity of metallothioneins to the zinc ions indicates their significant participation in the physiological, but also pathological processes, which are controlled by zinc. This paper summarizes the connection between metallothioneins and zinc and its significance on the molecular basis. Zinc as an essential element plays the crucial role in many physiological, but also pathological processes - zinc controls cell proliferation, differentiation, and viability including the apoptosis. These facts are especially based on the structural role of zinc ions in many proteins including the transcription factors. Due to the role of zinc in many crucial physiological processes, its homeostasis must be intensively controlled. The controlling mechanisms are based especially on the zinc transporters and low-molecular proteins metallothioneins (MTs) of the molecular weight between 6 and 10 kDa, which were firstly discovered in a horse kidneys as the cadmium binding protein. High affinity of metallothioneins to the zinc ions indicates their significant participation in the physiological, but also pathological processes, which are controlled by zinc. This paper summarizes the connection between metallothioneins and zinc and its significance on the molecular basis.
dcterms:title
Pharmaceutical importance of zinc and metallothionein in cell signaling. Pharmaceutical importance of zinc and metallothionein in cell signaling.
skos:prefLabel
Pharmaceutical importance of zinc and metallothionein in cell signaling. Pharmaceutical importance of zinc and metallothionein in cell signaling.
skos:notation
RIV/00216224:14110/10:00040866!RIV11-MZ0-14110___
n3:aktivita
n15:V n15:S n15:P
n3:aktivity
P(NS10200), S, V
n3:cisloPeriodika
6
n3:dodaniDat
n8:2011
n3:domaciTvurceVysledku
n4:3764419 n4:5070465 n4:4995775 n4:9600426
n3:druhVysledku
n16:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
278706
n3:idVysledku
RIV/00216224:14110/10:00040866
n3:jazykVysledku
n18:eng
n3:klicovaSlova
Metalloprotein; Metal; Transporter; Pathogenesis; Cancer
n3:klicoveSlovo
n5:Pathogenesis n5:Metal n5:Transporter n5:Cancer n5:Metalloprotein
n3:kodStatuVydavatele
IT - Italská republika
n3:kontrolniKodProRIV
[471C66D86B0B]
n3:nazevZdroje
Chimica Oggi/Chemistry today
n3:obor
n6:FR
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
6
n3:projekt
n17:NS10200
n3:rokUplatneniVysledku
n8:2010
n3:svazekPeriodika
28
n3:tvurceVysledku
Daňková, Ivana Masařík, Michal Babula, Petr Kohoutková, Veronika Opatřilová, Radka Kizek, René
s:issn
0392-839X
s:numberOfPages
4
n10:organizacniJednotka
14110