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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F09%3A00036369%21RIV11-MSM-14110___
rdf:type
skos:Concept n13:Vysledek
dcterms:description
In recent years, several independent prognostic factors in cytogenetically normal acute myeloid leukemia (CN-AML) have been reported. Mutations or the expression levels of certatin genes have been often used as molecular markers for preidiction of a patients outcome or for evaluation of treatment outcome. One of them, the gene encoding CCAAT/enhanced binding protein alpha (CEBPA), plays an important role in myeloid differentiation and, whn mutated, confers a favorable prognosis for patients with CN-AML. Complete mutation screening of the CEBPA gene is therefore beneficial and requires fast, precise, and sensitive diagnostic tools. Thus, for routine diagnostics, we developed a screening method using high-resolution melt curve analysis prior to direct sequencing, where only positive samples (according to reference) are further sequenced. In recent years, several independent prognostic factors in cytogenetically normal acute myeloid leukemia (CN-AML) have been reported. Mutations or the expression levels of certatin genes have been often used as molecular markers for preidiction of a patients outcome or for evaluation of treatment outcome. One of them, the gene encoding CCAAT/enhanced binding protein alpha (CEBPA), plays an important role in myeloid differentiation and, whn mutated, confers a favorable prognosis for patients with CN-AML. Complete mutation screening of the CEBPA gene is therefore beneficial and requires fast, precise, and sensitive diagnostic tools. Thus, for routine diagnostics, we developed a screening method using high-resolution melt curve analysis prior to direct sequencing, where only positive samples (according to reference) are further sequenced.
dcterms:title
CEBPA Gene mutational status A complete screening using high-resolution melt curve analysis CEBPA Gene mutational status A complete screening using high-resolution melt curve analysis
skos:prefLabel
CEBPA Gene mutational status A complete screening using high-resolution melt curve analysis CEBPA Gene mutational status A complete screening using high-resolution melt curve analysis
skos:notation
RIV/00216224:14110/09:00036369!RIV11-MSM-14110___
n3:aktivita
n10:V n10:Z
n3:aktivity
V, Z(MSM0021622430)
n3:cisloPeriodika
3
n3:dodaniDat
n6:2011
n3:domaciTvurceVysledku
n4:4585623 n4:3004880 n4:4376285 n4:5378605
n3:druhVysledku
n15:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
306192
n3:idVysledku
RIV/00216224:14110/09:00036369
n3:jazykVysledku
n14:eng
n3:klicovaSlova
acute myeloid leukemia; CEBPA mutation
n3:klicoveSlovo
n5:acute%20myeloid%20leukemia n5:CEBPA%20mutation
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[EAB069696207]
n3:nazevZdroje
Molecular diagnosis and therapy
n3:obor
n8:FD
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
6
n3:rokUplatneniVysledku
n6:2009
n3:svazekPeriodika
13
n3:tvurceVysledku
Jurček, Tomáš Dvořáková, Dana Křístková, Zlatuše Mayer, Jiří Ježíšková, Ivana Rázga, Filip
n3:wos
000269290600004
n3:zamer
n18:MSM0021622430
s:issn
1177-1062
s:numberOfPages
6
n17:organizacniJednotka
14110