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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F09%3A00035765%21RIV11-MZ0-14110___
rdf:type
skos:Concept n19:Vysledek
dcterms:description
MicroRNAs (miRNAs) are short, non-coding RNAs, which function as evolutionary conserved regulators of a gene expression. They have essential roles in development, cell differentiation, proliferation, apoptosis and chromosome structure. MiRNAs constitute about 3-5% of predicted genes in the human genome (i.e. about 1000); and 20-30% of the protein-coding genes are estimated to be regulated by the miRNAs. The primary evidence that miRNAs possibly act as a novel class of oncogenes/tumor-suppressors comes from the discovery of the miR-15a and miR-16-1 in 13q14 region deleted in chronic lymphocytic leukemia (CLL). Moreover, miRNA signatures have been used to classify tumor types. There have recently been several reports on the miRNAs role in CLL pathogenesis and disease subtypes (according to IgVH mutation status). In this report, we will review the published observations and present our miRNA profiling data in aggressive CLL with TP53 abnormalities (deletion and/or mutation of p53 gene). MicroRNAs (miRNAs) are short, non-coding RNAs, which function as evolutionary conserved regulators of a gene expression. They have essential roles in development, cell differentiation, proliferation, apoptosis and chromosome structure. MiRNAs constitute about 3-5% of predicted genes in the human genome (i.e. about 1000); and 20-30% of the protein-coding genes are estimated to be regulated by the miRNAs. The primary evidence that miRNAs possibly act as a novel class of oncogenes/tumor-suppressors comes from the discovery of the miR-15a and miR-16-1 in 13q14 region deleted in chronic lymphocytic leukemia (CLL). Moreover, miRNA signatures have been used to classify tumor types. There have recently been several reports on the miRNAs role in CLL pathogenesis and disease subtypes (according to IgVH mutation status). In this report, we will review the published observations and present our miRNA profiling data in aggressive CLL with TP53 abnormalities (deletion and/or mutation of p53 gene).
dcterms:title
MicroRNAs in chronic lymphocytic leukemia pathogenesis and disease subtype. MicroRNAs in chronic lymphocytic leukemia pathogenesis and disease subtype.
skos:prefLabel
MicroRNAs in chronic lymphocytic leukemia pathogenesis and disease subtype. MicroRNAs in chronic lymphocytic leukemia pathogenesis and disease subtype.
skos:notation
RIV/00216224:14110/09:00035765!RIV11-MZ0-14110___
n3:aktivita
n10:Z n10:P
n3:aktivity
P(NR9293), Z(MSM0021622430)
n3:cisloPeriodika
3
n3:dodaniDat
n9:2011
n3:domaciTvurceVysledku
n8:1957864 n8:4382749 n8:5635896 n8:4376285 n8:3655083
n3:druhVysledku
n18:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n5:predkladatel
n3:idSjednocenehoVysledku
326207
n3:idVysledku
RIV/00216224:14110/09:00035765
n3:jazykVysledku
n11:eng
n3:klicovaSlova
CLL; p53; miR-34a; miR-29c; miR-17-5p
n3:klicoveSlovo
n4:miR-17-5p n4:miR-34a n4:miR-29c n4:CLL n4:p53
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[6AA9A1EFEF98]
n3:nazevZdroje
LEUKEMIA & LYMPHOMA
n3:obor
n17:FD
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:projekt
n14:NR9293
n3:rokUplatneniVysledku
n9:2009
n3:svazekPeriodika
50
n3:tvurceVysledku
Mráz, Marek Mayer, Jiří Plevová, Karla Pospíšilová, Šárka Šlapák, Ivo
n3:wos
000265361100040
n3:zamer
n12:MSM0021622430
s:issn
1042-8194
s:numberOfPages
4
n16:organizacniJednotka
14110