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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F09%3A00029671%21RIV11-GA0-14110___
rdf:type
n9:Vysledek skos:Concept
dcterms:description
The supposed role of cardiac sigma receptors is fine tuning of contractility. They affect several ion channels, and hence their signaling is reflected by the electrophysiological properties of the heart. Numerous ligands of sigma receptors are known to prolong QT interval and therefore cause a variety of arrhythmias, including the severe ones. The effects of prototypical sigma ligand haloperidol have been repeatedly studied in humans as well as in various animal models. We examined the incidence of arrhythmias, changes in heart rate, QT interval in isolated Langendorff-perfused rat and guinea pig hearts after they were exposed to nanomolar concentration of haloperidol. Hearts from both untreated and chronically to haloperidol exposed animals were investigated. While due to haloperidol administration, the QT prolongation and arrhythmias were observed in untreated rat and guinea pig hearts, arrhythmias were completely prevented in both chronically treated species. The supposed role of cardiac sigma receptors is fine tuning of contractility. They affect several ion channels, and hence their signaling is reflected by the electrophysiological properties of the heart. Numerous ligands of sigma receptors are known to prolong QT interval and therefore cause a variety of arrhythmias, including the severe ones. The effects of prototypical sigma ligand haloperidol have been repeatedly studied in humans as well as in various animal models. We examined the incidence of arrhythmias, changes in heart rate, QT interval in isolated Langendorff-perfused rat and guinea pig hearts after they were exposed to nanomolar concentration of haloperidol. Hearts from both untreated and chronically to haloperidol exposed animals were investigated. While due to haloperidol administration, the QT prolongation and arrhythmias were observed in untreated rat and guinea pig hearts, arrhythmias were completely prevented in both chronically treated species.
dcterms:title
Apparent desensitization of the effects of sigma receptor ligand haloperidol in isolated rat and guinea pig hearts after chronic treatment Apparent desensitization of the effects of sigma receptor ligand haloperidol in isolated rat and guinea pig hearts after chronic treatment
skos:prefLabel
Apparent desensitization of the effects of sigma receptor ligand haloperidol in isolated rat and guinea pig hearts after chronic treatment Apparent desensitization of the effects of sigma receptor ligand haloperidol in isolated rat and guinea pig hearts after chronic treatment
skos:notation
RIV/00216224:14110/09:00029671!RIV11-GA0-14110___
n3:aktivita
n12:Z n12:P
n3:aktivity
P(GA102/07/1473), Z(MSM0021622402)
n3:cisloPeriodika
12
n3:dodaniDat
n13:2011
n3:domaciTvurceVysledku
n15:9478426 n15:5074169 n15:1469517
n3:druhVysledku
n14:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
303723
n3:idVysledku
RIV/00216224:14110/09:00029671
n3:jazykVysledku
n19:eng
n3:klicovaSlova
haloperidol; sigma receptor; desensitization; rat; guinea pig; isolated heart; QT interval; arrhythmia
n3:klicoveSlovo
n5:sigma%20receptor n5:rat n5:arrhythmia n5:desensitization n5:haloperidol n5:QT%20interval n5:isolated%20heart n5:guinea%20pig
n3:kodStatuVydavatele
CA - Kanada
n3:kontrolniKodProRIV
[0BE7C5465C36]
n3:nazevZdroje
Canadian Journal of Physiology and Pharmacology
n3:obor
n17:ED
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
4
n3:projekt
n7:GA102%2F07%2F1473
n3:rokUplatneniVysledku
n13:2009
n3:svazekPeriodika
87
n3:tvurceVysledku
Jarkovský, Jiří Krizanova, Olga Nováková, Marie Fialová, Kateřina
n3:wos
000273419000006
n3:zamer
n18:MSM0021622402
s:issn
1205-7541
s:numberOfPages
9
n16:organizacniJednotka
14110