This HTML5 document contains 47 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
n6http://linked.opendata.cz/ontology/domain/vavai/riv/typAkce/
n5http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00216224%3A14110%2F08%3A00028239%21RIV10-MZ0-14110___/
dctermshttp://purl.org/dc/terms/
n19http://localhost/temp/predkladatel/
n10http://purl.org/net/nknouf/ns/bibtex#
n20http://linked.opendata.cz/resource/domain/vavai/projekt/
n4http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n11http://linked.opendata.cz/ontology/domain/vavai/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n13http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n17http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n14http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n9http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n16http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n7http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n18http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F08%3A00028239%21RIV10-MZ0-14110___
rdf:type
n11:Vysledek skos:Concept
dcterms:description
MicroRNAs (miRNAs) are endogenously expressed short non-coding RNAs, that repress protein translation through binding to target mRNAs. Although the number of verified human miRNA is still expanding, only few have been functionally described. However, emerging evidences suggest the involvement of altered regulation of miRNA in pathogenesis of cancers and these genes are thought to function as both tumours suppressor and oncogenes. Previous studies, mainly based on microarrays technology applied on colorectal cancer cell lines, showed altered expression levels of several miRNAs in colorectal cancer (CRC). In our study, we examined by Real-Time PCR expression levels of microRNA-21 (miR-21) in tumors of 29 colorectal cancer patients. For 6 cases of CRC samples also adjacent non-tumor tissues were analyzed. For data normalization we tried different approaches (18S rRNA, GAPDH, let-7a-1). Finally, variability of let-7a-1 expression was shown to be the lowest. MicroRNAs (miRNAs) are endogenously expressed short non-coding RNAs, that repress protein translation through binding to target mRNAs. Although the number of verified human miRNA is still expanding, only few have been functionally described. However, emerging evidences suggest the involvement of altered regulation of miRNA in pathogenesis of cancers and these genes are thought to function as both tumours suppressor and oncogenes. Previous studies, mainly based on microarrays technology applied on colorectal cancer cell lines, showed altered expression levels of several miRNAs in colorectal cancer (CRC). In our study, we examined by Real-Time PCR expression levels of microRNA-21 (miR-21) in tumors of 29 colorectal cancer patients. For 6 cases of CRC samples also adjacent non-tumor tissues were analyzed. For data normalization we tried different approaches (18S rRNA, GAPDH, let-7a-1). Finally, variability of let-7a-1 expression was shown to be the lowest.
dcterms:title
Significance of microRNA-21 in colorectal cancer pathogenesis. Significance of microRNA-21 in colorectal cancer pathogenesis.
skos:prefLabel
Significance of microRNA-21 in colorectal cancer pathogenesis. Significance of microRNA-21 in colorectal cancer pathogenesis.
skos:notation
RIV/00216224:14110/08:00028239!RIV10-MZ0-14110___
n3:aktivita
n14:P
n3:aktivity
P(NR9076)
n3:dodaniDat
n18:2010
n3:domaciTvurceVysledku
n4:5974291 n4:2912589 n4:7623933 n4:6760074
n3:druhVysledku
n7:D
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n5:predkladatel
n3:idSjednocenehoVysledku
394693
n3:idVysledku
RIV/00216224:14110/08:00028239
n3:jazykVysledku
n9:eng
n3:klicovaSlova
colorectal; microRNAs
n3:klicoveSlovo
n13:colorectal n13:microRNAs
n3:kontrolniKodProRIV
[BC18C7BED89B]
n3:mistoKonaniAkce
Athens
n3:mistoVydani
Oxford, UK
n3:nazevZdroje
FEBS Journal
n3:obor
n16:FD
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
7
n3:projekt
n20:NR9076
n3:rokUplatneniVysledku
n18:2008
n3:tvurceVysledku
Slabý, Ondřej Hrstka, Roman Vyzula, Rostislav Růčková, Eva Ovesná, Jaroslava Svoboda, Marek Dubská, Lenka
n3:typAkce
n6:WRD
n3:zahajeniAkce
2008-01-01+01:00
s:issn
1742-464X
s:numberOfPages
1
n10:hasPublisher
FEBS
n19:organizacniJednotka
14110