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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F08%3A00028213%21RIV10-MZ0-14110___
rdf:type
skos:Concept n16:Vysledek
dcterms:description
Diabetic complications including diabetic nephropathy (DN) develop due to the complex dysregulation of cellular metabolism during hyperglycemia. Accumulation of proximal glycolytic intermediates provides substrates for several alternative metabolic pathways producing harmful moieties such as advanced glycation end-products, dicarbonyls, sorbitol, hexosamines, reactive oxygen and nitrogen species etc. Pentose phosphate pathway (PPP) represents potentially %22protective%22 mechanism in hyperglycemia since shunting of cumulated glycolytic intermediates (esp. triosephosphates) into the PPP reactions quantitatively limits their processing in alternative metabolic pathways. We hypothesized that genetic variability in genes encoding key enzymes of PPP - transketolase (TKT), transaldolase, TKT-like and glucose-6-phosphate dehydrogenase - together with thiamin status (thiamine and its esters - cofactors of TKT) might contribute to an interindividual variability in the onset and progression of DN. Diabetic complications including diabetic nephropathy (DN) develop due to the complex dysregulation of cellular metabolism during hyperglycemia. Accumulation of proximal glycolytic intermediates provides substrates for several alternative metabolic pathways producing harmful moieties such as advanced glycation end-products, dicarbonyls, sorbitol, hexosamines, reactive oxygen and nitrogen species etc. Pentose phosphate pathway (PPP) represents potentially %22protective%22 mechanism in hyperglycemia since shunting of cumulated glycolytic intermediates (esp. triosephosphates) into the PPP reactions quantitatively limits their processing in alternative metabolic pathways. We hypothesized that genetic variability in genes encoding key enzymes of PPP - transketolase (TKT), transaldolase, TKT-like and glucose-6-phosphate dehydrogenase - together with thiamin status (thiamine and its esters - cofactors of TKT) might contribute to an interindividual variability in the onset and progression of DN.
dcterms:title
Thiamine Status and Genetic Variability in the Pentose Phosphate Cycle Enzymes as Risk Factors for Diabetic Nephropathy Thiamine Status and Genetic Variability in the Pentose Phosphate Cycle Enzymes as Risk Factors for Diabetic Nephropathy
skos:prefLabel
Thiamine Status and Genetic Variability in the Pentose Phosphate Cycle Enzymes as Risk Factors for Diabetic Nephropathy Thiamine Status and Genetic Variability in the Pentose Phosphate Cycle Enzymes as Risk Factors for Diabetic Nephropathy
skos:notation
RIV/00216224:14110/08:00028213!RIV10-MZ0-14110___
n3:aktivita
n15:S n15:P
n3:aktivity
P(NR9443), S
n3:dodaniDat
n6:2010
n3:domaciTvurceVysledku
n8:3648753 n8:8929343 n8:7390343 n8:7988788 n8:6108768 n8:7289006 n8:5105374 n8:2529947 n8:5117070 n8:6452957
n3:druhVysledku
n11:O
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
399955
n3:idVysledku
RIV/00216224:14110/08:00028213
n3:jazykVysledku
n9:eng
n3:klicovaSlova
diabetic nephropathy; pentose phosphate pathway; transketolase; thiamin
n3:klicoveSlovo
n4:pentose%20phosphate%20pathway n4:diabetic%20nephropathy n4:thiamin n4:transketolase
n3:kontrolniKodProRIV
[E496270E9B8B]
n3:obor
n10:FB
n3:pocetDomacichTvurcuVysledku
10
n3:pocetTvurcuVysledku
12
n3:projekt
n14:NR9443
n3:rokUplatneniVysledku
n6:2008
n3:tvurceVysledku
Tomandl, Josef Svojanovský, Jan Kaňková, Kateřina Krusová, Darja Smržová, Jana Řehořová, Jitka Olšovský, Jindřich Hertlová, Miluše Štěpánková, Soňa Šurel, Stanislav Tanhäuserová, Veronika Pácal, Lukáš
n13:organizacniJednotka
14110