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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F08%3A00024909%21RIV11-GA0-14110___
rdf:type
n13:Vysledek skos:Concept
dcterms:description
Osteoclasts (OCL) and dendritic cells (DC) are highly specialized cells that originate from a common hematopoetic progenitor. The osteoclasts are involved in bone resorption; dendritic cells represent a key compound of immune system as antigen presenting cells. Despite distinct functions, similar signaling molecules are involved in control of differentiation of OCL and DC. These regulators include integrin b3, the ECM receptor, and transcription factors c-Jun and c-Fos (AP-1). To investigate the signaling crosstalk between Itgb3 and AP-1 in OCL and DC, we employed murine model of RAW264.7 macrophages. These cells differentiate to OCL or DC upon treatment with RANKL (Receptor activator of NFkB ligand)MCSF or LPS (Lipopolysacharide). Expression of itgb3, c-jun and c-fos as well as differentiation markers were determined at mRNA level by qRT-PCR or western blotting. Expression of itgb3 was induced by both RANKL MCSF and LPS; however, expression of c-fos and c-jun was regulated differently in DC and OCL. Osteoclasts (OCL) and dendritic cells (DC) are highly specialized cells that originate from a common hematopoetic progenitor. The osteoclasts are involved in bone resorption; dendritic cells represent a key compound of immune system as antigen presenting cells. Despite distinct functions, similar signaling molecules are involved in control of differentiation of OCL and DC. These regulators include integrin b3, the ECM receptor, and transcription factors c-Jun and c-Fos (AP-1). To investigate the signaling crosstalk between Itgb3 and AP-1 in OCL and DC, we employed murine model of RAW264.7 macrophages. These cells differentiate to OCL or DC upon treatment with RANKL (Receptor activator of NFkB ligand)MCSF or LPS (Lipopolysacharide). Expression of itgb3, c-jun and c-fos as well as differentiation markers were determined at mRNA level by qRT-PCR or western blotting. Expression of itgb3 was induced by both RANKL MCSF and LPS; however, expression of c-fos and c-jun was regulated differently in DC and OCL.
dcterms:title
Functional cross-talk of integrin b3 and AP-1 in differentiating osteoclasts and dendritic cells. Functional cross-talk of integrin b3 and AP-1 in differentiating osteoclasts and dendritic cells.
skos:prefLabel
Functional cross-talk of integrin b3 and AP-1 in differentiating osteoclasts and dendritic cells. Functional cross-talk of integrin b3 and AP-1 in differentiating osteoclasts and dendritic cells.
skos:notation
RIV/00216224:14110/08:00024909!RIV11-GA0-14110___
n3:aktivita
n10:Z n10:P
n3:aktivity
P(GA301/06/0036), P(GD204/08/H054), Z(MSM0021622415)
n3:dodaniDat
n14:2011
n3:domaciTvurceVysledku
n7:1642537 n7:6723381 n7:6659446 n7:5687683
n3:druhVysledku
n16:D
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
368680
n3:idVysledku
RIV/00216224:14110/08:00024909
n3:jazykVysledku
n21:eng
n3:klicovaSlova
osteoclasts; dendritic cells; integrin beta 3; AP-1
n3:klicoveSlovo
n4:AP-1 n4:integrin%20beta%203 n4:osteoclasts n4:dendritic%20cells
n3:kontrolniKodProRIV
[40E10B5AF200]
n3:mistoKonaniAkce
Warsaw, Poland
n3:mistoVydani
Warsaw
n3:nazevZdroje
Book of Abstracts
n3:obor
n11:EB
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n12:GD204%2F08%2FH054 n12:GA301%2F06%2F0036
n3:rokUplatneniVysledku
n14:2008
n3:tvurceVysledku
Ondroušková, Eva Vaňhara, Petr Šmarda, Jan Vopěnková, Kateřina
n3:typAkce
n9:WRD
n3:zahajeniAkce
2008-09-10+02:00
n3:zamer
n19:MSM0021622415
s:numberOfPages
2
n22:hasPublisher
International Life Sciences Students's Conference
n17:isbn
978-83-927731-0-8
n20:organizacniJednotka
14110