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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F07%3A00023553%21RIV10-MSM-14110___
rdf:type
n4:Vysledek skos:Concept
dcterms:description
Glutathione S-transferase (GST) enzymes play an important role in cellular protection against oxidative stress and toxic foreign chemicals. So, we investigated the hypothesis that polymorphisms in genes for these detoxifying enzymes could influence susceptibility to RE and Barrett s esophagus. Methods: GSTM1, GSTT1 and GSTP1 loci were analyzed by PCR-based methods in 64 patients with RE (and additional group of 22 subjects with Barrett s esophagus as 4th grade of esophagitis) and 173 unrelated controls.Results: There were no significant differences in the distributions of GSTM1 and GSTT1 genotypes between controls and patients with RE or Barrett s esophagus. Similarly, frequencies of GSTP1 alleles were non-significantly different between control and reflux esophagitis groups. Conclusions: GSTP1 gene might be one of the risk factors associated with susceptibility to reflux esophagitis, especially to Barrett s esophagus. Glutathione S-transferase (GST) enzymes play an important role in cellular protection against oxidative stress and toxic foreign chemicals. So, we investigated the hypothesis that polymorphisms in genes for these detoxifying enzymes could influence susceptibility to RE and Barrett s esophagus. Methods: GSTM1, GSTT1 and GSTP1 loci were analyzed by PCR-based methods in 64 patients with RE (and additional group of 22 subjects with Barrett s esophagus as 4th grade of esophagitis) and 173 unrelated controls.Results: There were no significant differences in the distributions of GSTM1 and GSTT1 genotypes between controls and patients with RE or Barrett s esophagus. Similarly, frequencies of GSTP1 alleles were non-significantly different between control and reflux esophagitis groups. Conclusions: GSTP1 gene might be one of the risk factors associated with susceptibility to reflux esophagitis, especially to Barrett s esophagus.
dcterms:title
Polymorhism of glutathione S-transferase M1, T1 and P1 in patients with reflux esophagitis and Barrett´s esophagus Polymorhism of glutathione S-transferase M1, T1 and P1 in patients with reflux esophagitis and Barrett´s esophagus
skos:prefLabel
Polymorhism of glutathione S-transferase M1, T1 and P1 in patients with reflux esophagitis and Barrett´s esophagus Polymorhism of glutathione S-transferase M1, T1 and P1 in patients with reflux esophagitis and Barrett´s esophagus
skos:notation
RIV/00216224:14110/07:00023553!RIV10-MSM-14110___
n3:aktivita
n11:P
n3:aktivity
P(2B06060)
n3:cisloPeriodika
6
n3:dodaniDat
n13:2010
n3:domaciTvurceVysledku
n17:8614628 n17:1203339
n3:druhVysledku
n5:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
442209
n3:idVysledku
RIV/00216224:14110/07:00023553
n3:jazykVysledku
n6:eng
n3:klicovaSlova
GERD; GSTs; glutathione S-transferase; polymorphism; reflux esophagitis; gene
n3:klicoveSlovo
n7:GERD n7:gene n7:glutathione%20S-transferase n7:polymorphism n7:GSTs n7:reflux%20esophagitis
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[34450D8F1A64]
n3:nazevZdroje
Journal of Hum Genetics
n3:obor
n15:FJ
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
4
n3:projekt
n8:2B06060
n3:rokUplatneniVysledku
n13:2007
n3:svazekPeriodika
52
n3:tvurceVysledku
Marek, F. Kala, Zdeněk Dolina, Jiří Izakovičová-Holá, L.
s:issn
1434-5161
s:numberOfPages
8
n18:organizacniJednotka
14110