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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F07%3A00022464%21RIV10-MSM-14110___
rdf:type
n12:Vysledek skos:Concept
dcterms:description
The aim of the study was to compare the distribution of therapeutic efficacy and sexual dysfunction during maintenance paroxetine treatment in 17 males and 38 females genotyped and phenotyped to determine their CYP2D6 metabolic status. The phenotype procedure showed 7 males and 12 females with extensive metabolic status (EM) and 10 males and 26 females with poor metabolic status (PM). No variation in therapeutic efficacy between male and female subjects classified as PM and those marked as EM was found. A significantly higher rate of sexual dysfunction (p=0,01) was recorded among females with a PM phenotype. The aim of the study was to compare the distribution of therapeutic efficacy and sexual dysfunction during maintenance paroxetine treatment in 17 males and 38 females genotyped and phenotyped to determine their CYP2D6 metabolic status. The phenotype procedure showed 7 males and 12 females with extensive metabolic status (EM) and 10 males and 26 females with poor metabolic status (PM). No variation in therapeutic efficacy between male and female subjects classified as PM and those marked as EM was found. A significantly higher rate of sexual dysfunction (p=0,01) was recorded among females with a PM phenotype.
dcterms:title
Links among paroxetine-induced sexual dysfunctions, gender, and CYP2D6 activity Links among paroxetine-induced sexual dysfunctions, gender, and CYP2D6 activity
skos:prefLabel
Links among paroxetine-induced sexual dysfunctions, gender, and CYP2D6 activity Links among paroxetine-induced sexual dysfunctions, gender, and CYP2D6 activity
skos:notation
RIV/00216224:14110/07:00022464!RIV10-MSM-14110___
n3:aktivita
n9:Z
n3:aktivity
Z(MSM0021622404)
n3:cisloPeriodika
5
n3:dodaniDat
n5:2010
n3:domaciTvurceVysledku
n4:3871029 n4:8110549 n4:6114067 n4:1296396
n3:druhVysledku
n11:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
431155
n3:idVysledku
RIV/00216224:14110/07:00022464
n3:jazykVysledku
n18:eng
n3:klicovaSlova
paroxetine - CYP2D6 - gender - sexual dysfunction
n3:klicoveSlovo
n13:paroxetine
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[0870FD3F0FA3]
n3:nazevZdroje
Journal of Sex and Marital Therapy
n3:obor
n17:FL
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n5:2007
n3:svazekPeriodika
33
n3:tvurceVysledku
Češková, Eva Ravčuková, Barbora McCaskey Hadašová, Eva Žourková, Alexandra
n3:wos
000247599700006
n3:zamer
n15:MSM0021622404
s:issn
0092-623X
s:numberOfPages
13
n14:organizacniJednotka
14110