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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F07%3A00020083%21RIV10-GA0-14110___
rdf:type
n11:Vysledek skos:Concept
dcterms:description
Quaternary benzo[c]phenanthridine alkaloids are a relatively small group of isoquinoline alkaloids with attractive biological activities. They are produced by a number of plant species of the Papaveraceae, Fumariaceae and Rutaceae families. Differential cytotoxicity of minor naturally occurring derivatives sanguirubine, chelirubine and macarpine and better known benzophenanthridines sanguinarine and chelerythrine in cancer and normal cells was assessed in vitro by MTT assay using a panel consisting of either transformed cell lines (HeLa; A431; HL60) or primary fibroblasts of human origin. IC50 values were determined 72 h after addition of the alkaloids. A wide range (0.01-1.44 mg/ml) of IC50 was observed and the highest toxicity was determined for macarpine. Human promyelocytic leukemia line HL60 has been documented the most sensitive to alkaloid treatment followed by human skin fibroblasts, while human cervix adenocarcinoma HeLa cells and epidermal carcinoma cells A431 appeared more resistant. Quaternary benzo[c]phenanthridine alkaloids are a relatively small group of isoquinoline alkaloids with attractive biological activities. They are produced by a number of plant species of the Papaveraceae, Fumariaceae and Rutaceae families. Differential cytotoxicity of minor naturally occurring derivatives sanguirubine, chelirubine and macarpine and better known benzophenanthridines sanguinarine and chelerythrine in cancer and normal cells was assessed in vitro by MTT assay using a panel consisting of either transformed cell lines (HeLa; A431; HL60) or primary fibroblasts of human origin. IC50 values were determined 72 h after addition of the alkaloids. A wide range (0.01-1.44 mg/ml) of IC50 was observed and the highest toxicity was determined for macarpine. Human promyelocytic leukemia line HL60 has been documented the most sensitive to alkaloid treatment followed by human skin fibroblasts, while human cervix adenocarcinoma HeLa cells and epidermal carcinoma cells A431 appeared more resistant.
dcterms:title
Screening of minor benzo(c)phenanthridine alkaloids for antiproliferative and apoptotic activities. Screening of minor benzo(c)phenanthridine alkaloids for antiproliferative and apoptotic activities.
skos:prefLabel
Screening of minor benzo(c)phenanthridine alkaloids for antiproliferative and apoptotic activities. Screening of minor benzo(c)phenanthridine alkaloids for antiproliferative and apoptotic activities.
skos:notation
RIV/00216224:14110/07:00020083!RIV10-GA0-14110___
n3:aktivita
n5:P n5:Z
n3:aktivity
P(GA525/04/0017), P(GD301/03/H005), Z(MSM0021622415)
n3:cisloPeriodika
2
n3:dodaniDat
n8:2010
n3:domaciTvurceVysledku
n7:3682455 n7:1027530 n7:9540539 n7:6987729
n3:druhVysledku
n18:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
449063
n3:idVysledku
RIV/00216224:14110/07:00020083
n3:jazykVysledku
n16:eng
n3:klicovaSlova
apoptosis; annexin V; benzo[c]phenanthridine alkaloids; cytotoxicity; chelerythrine; chelirubine; macarpine; MTT assay; sanguinarine; sanguirubine
n3:klicoveSlovo
n4:sanguirubine n4:apoptosis n4:cytotoxicity n4:chelirubine n4:annexin%20V n4:sanguinarine n4:macarpine n4:MTT%20assay n4:chelerythrine n4:benzo%5Bc%5Dphenanthridine%20alkaloids
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[04435F678F88]
n3:nazevZdroje
Pharmaceutical Biology
n3:obor
n6:EB
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
5
n3:projekt
n17:GA525%2F04%2F0017 n17:GD301%2F03%2FH005
n3:rokUplatneniVysledku
n8:2007
n3:svazekPeriodika
45
n3:tvurceVysledku
Táborská, Eva Slaninová, Iva Šinkora, Jiří Slunská, Zdenka Vlková, Marcela
n3:wos
000245677200009
n3:zamer
n19:MSM0021622415
s:issn
1388-0209
s:numberOfPages
10
n13:organizacniJednotka
14110