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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F07%3A00019138%21RIV10-MZ0-14110___
rdf:type
n16:Vysledek skos:Concept
dcterms:description
Background: The risk of POF onset depends mainly on womens age and foliculogenesis status in ovary, chemotherapy (CT) regimen used and cumulative dose of single cytotoxic agents. Aims: Aim of this prospective case-control study is evaluation of gonadoliberine analogues (GnRHa) administration to patients with Hodgkins lymphoma (HL) during chemotherapy and prevention of ovarian damage depending upon CT dose and regimen. Methods: Study group consists of 72 patients in fertile age with HL by curative CT together with GnRHa administration according standardized protocol. Group A received ABVD, group B baseline BEACOPP and ABVD in combination, group C dose escalated BEACOPP regimen. Results: In study group with GnRHa administration during CT there was statistical significantly less cases with POF (38.2 %) in 6 month after end of CT than in control group (73.4 %). After 12 month POF was detected in 48.8 % of cases versus 69.3 % in control group. Background: The risk of POF onset depends mainly on womens age and foliculogenesis status in ovary, chemotherapy (CT) regimen used and cumulative dose of single cytotoxic agents. Aims: Aim of this prospective case-control study is evaluation of gonadoliberine analogues (GnRHa) administration to patients with Hodgkins lymphoma (HL) during chemotherapy and prevention of ovarian damage depending upon CT dose and regimen. Methods: Study group consists of 72 patients in fertile age with HL by curative CT together with GnRHa administration according standardized protocol. Group A received ABVD, group B baseline BEACOPP and ABVD in combination, group C dose escalated BEACOPP regimen. Results: In study group with GnRHa administration during CT there was statistical significantly less cases with POF (38.2 %) in 6 month after end of CT than in control group (73.4 %). After 12 month POF was detected in 48.8 % of cases versus 69.3 % in control group.
dcterms:title
Prevention of ovarian damage during chemotherapy by gonadoliberine analogues administration Prevention of ovarian damage during chemotherapy by gonadoliberine analogues administration
skos:prefLabel
Prevention of ovarian damage during chemotherapy by gonadoliberine analogues administration Prevention of ovarian damage during chemotherapy by gonadoliberine analogues administration
skos:notation
RIV/00216224:14110/07:00019138!RIV10-MZ0-14110___
n4:aktivita
n17:P
n4:aktivity
P(NR8469)
n4:dodaniDat
n7:2010
n4:domaciTvurceVysledku
n10:5898455 n10:4996291 n10:6796451 n10:1241184 n10:9890009 n10:4239350
n4:druhVysledku
n5:O
n4:duvernostUdaju
n6:S
n4:entitaPredkladatele
n11:predkladatel
n4:idSjednocenehoVysledku
444033
n4:idVysledku
RIV/00216224:14110/07:00019138
n4:jazykVysledku
n14:eng
n4:klicovaSlova
Hodgkins lymphoma; gonadoliberine analogues; premature ovarian failure
n4:klicoveSlovo
n9:Hodgkins%20lymphoma n9:gonadoliberine%20analogues n9:premature%20ovarian%20failure
n4:kontrolniKodProRIV
[227B2728BEE5]
n4:obor
n15:FK
n4:pocetDomacichTvurcuVysledku
6
n4:pocetTvurcuVysledku
6
n4:projekt
n12:NR8469
n4:rokUplatneniVysledku
n7:2007
n4:tvurceVysledku
Král, Zdeněk Huser, Martin Šmardová, Lenka Crha, Igor Ventruba, Pavel Vorlíček, Jiří
n8:organizacniJednotka
14110