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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F07%3A00019111%21RIV10-MZ0-14110___
rdf:type
skos:Concept n17:Vysledek
dcterms:description
Introduction Cytogenetic abnormalities in multiple myeloma (MM) are one of the most important independent prognostic factors. Based on cytogenetic findings MM patients (pts.) could be divided into prognostic groups. The aim of this study was to determine the correlation between the aberration of the chromosome 13, rearrangement of IGH gene, translocations t(11;14) and t(4;14), the deletion of 17p13 and the prognostic factors in the patients with newly diagnosed MM who underwent autologous transplantation (AT) according protocol of CMG 2002 trial. Materials and Methods Fluorescence in situ hybridization and cytoplasm immunoglobulin staining (cIg-FISH) were used to detect monotypic plasma cells and aberrations mentioned above. Cytogenetic abnormalities were found in 70 newly diagnosed patients with MM, median of follow-up 17,5 months, median age 57 years (39-67), DS stadium: stage I 7,1%, II 24,3%, III 68,6%; A/B - 84.3%/15.7%. Introduction Cytogenetic abnormalities in multiple myeloma (MM) are one of the most important independent prognostic factors. Based on cytogenetic findings MM patients (pts.) could be divided into prognostic groups. The aim of this study was to determine the correlation between the aberration of the chromosome 13, rearrangement of IGH gene, translocations t(11;14) and t(4;14), the deletion of 17p13 and the prognostic factors in the patients with newly diagnosed MM who underwent autologous transplantation (AT) according protocol of CMG 2002 trial. Materials and Methods Fluorescence in situ hybridization and cytoplasm immunoglobulin staining (cIg-FISH) were used to detect monotypic plasma cells and aberrations mentioned above. Cytogenetic abnormalities were found in 70 newly diagnosed patients with MM, median of follow-up 17,5 months, median age 57 years (39-67), DS stadium: stage I 7,1%, II 24,3%, III 68,6%; A/B - 84.3%/15.7%.
dcterms:title
CORRELATION BETWEEN CHROMOSOMAL ABERRATIONS AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION CORRELATION BETWEEN CHROMOSOMAL ABERRATIONS AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION
skos:prefLabel
CORRELATION BETWEEN CHROMOSOMAL ABERRATIONS AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION CORRELATION BETWEEN CHROMOSOMAL ABERRATIONS AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION
skos:notation
RIV/00216224:14110/07:00019111!RIV10-MZ0-14110___
n3:aktivita
n18:P
n3:aktivity
P(NR8183)
n3:dodaniDat
n5:2010
n3:domaciTvurceVysledku
n7:4240243 n7:1447963 n7:8352844 n7:9685596 n7:7227086 n7:2294761 n7:5283752 n7:6933300 n7:1765272 n7:9622748
n3:druhVysledku
n14:D
n3:duvernostUdaju
n20:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
415132
n3:idVysledku
RIV/00216224:14110/07:00019111
n3:jazykVysledku
n9:eng
n3:klicovaSlova
multiple myeloma; cIg FISH; chromosomal changes; autologous stem cell transplantation
n3:klicoveSlovo
n15:multiple%20myeloma n15:cIg%20FISH n15:chromosomal%20changes n15:autologous%20stem%20cell%20transplantation
n3:kontrolniKodProRIV
[4E44C98792CF]
n3:mistoKonaniAkce
Budapest, Hungary
n3:mistoVydani
Edinburgh
n3:nazevZdroje
Blood reviews
n3:obor
n6:EB
n3:pocetDomacichTvurcuVysledku
10
n3:pocetTvurcuVysledku
10
n3:projekt
n19:NR8183
n3:rokUplatneniVysledku
n5:2007
n3:tvurceVysledku
Kuglík, Petr Křivanová, Andrea Adam, Zdeněk Krejčí, Marta Filková, Hana Hájek, Roman Pour, Luděk Grešliková, Henrieta Oltová, Alexandra Smejkalová, Jana
n3:typAkce
n4:EUR
n3:zahajeniAkce
2007-08-29+02:00
s:issn
0268-960X
s:numberOfPages
1
n8:hasPublisher
Churchill Livingstone
n12:organizacniJednotka
14110