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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F07%3A00019043%21RIV10-MZ0-14110___
rdf:type
skos:Concept n19:Vysledek
dcterms:description
Oxidative stress, alterations in host immunity and inflammation may contribute to genesis and progression of head and neck squamous cell carcinoma (HNSCC). We investigated relationships between malondialdehyde (MDA) as a marker of lipid peroxidation and parameters of activated macrophages, i.e. tumor necrosis factor alpha as a marker of inflammation and neopterin as a marker of cell-mediated immunity and clinical stage of HNSCC. Our results confirm the role of activated macrophages and the cellular immune system in HNSCC. In patients with activated T-lymphocytes, levels of TNF alpha inversely reflected the prognosis of disease. Although production of MDA in HNSCC patients is normal, it seems that activated T-lymphocytes contribute to lipid peroxidation. Oxidative stress, alterations in host immunity and inflammation may contribute to genesis and progression of head and neck squamous cell carcinoma (HNSCC). We investigated relationships between malondialdehyde (MDA) as a marker of lipid peroxidation and parameters of activated macrophages, i.e. tumor necrosis factor alpha as a marker of inflammation and neopterin as a marker of cell-mediated immunity and clinical stage of HNSCC. Our results confirm the role of activated macrophages and the cellular immune system in HNSCC. In patients with activated T-lymphocytes, levels of TNF alpha inversely reflected the prognosis of disease. Although production of MDA in HNSCC patients is normal, it seems that activated T-lymphocytes contribute to lipid peroxidation.
dcterms:title
Relationship between parameters of cell-mediated immunity, oxidative stress and head and neck squamous cell carcinoma Relationship between parameters of cell-mediated immunity, oxidative stress and head and neck squamous cell carcinoma
skos:prefLabel
Relationship between parameters of cell-mediated immunity, oxidative stress and head and neck squamous cell carcinoma Relationship between parameters of cell-mediated immunity, oxidative stress and head and neck squamous cell carcinoma
skos:notation
RIV/00216224:14110/07:00019043!RIV10-MZ0-14110___
n3:aktivita
n20:P
n3:aktivity
P(NR7996), P(NR9200)
n3:dodaniDat
n18:2010
n3:domaciTvurceVysledku
n7:3648753 n7:8292159 n7:6900402 n7:2471752
n3:druhVysledku
n9:D
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
447187
n3:idVysledku
RIV/00216224:14110/07:00019043
n3:jazykVysledku
n21:eng
n3:klicovaSlova
head and neck cell carcinoma; oxidative stress; cell-mediated immunity
n3:klicoveSlovo
n4:head%20and%20neck%20cell%20carcinoma n4:oxidative%20stress n4:cell-mediated%20immunity
n3:kontrolniKodProRIV
[3D4283909EC6]
n3:mistoKonaniAkce
Bratislava
n3:mistoVydani
Bratislava
n3:nazevZdroje
Book of abstracts from the conference Synthetic and natural compounds in cancer therapy and prevention.
n3:obor
n11:CE
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n14:NR7996 n14:NR9200
n3:rokUplatneniVysledku
n18:2007
n3:tvurceVysledku
Salzman, Richard Kostřica, Rom Horáková, Zuzana Tomandl, Josef
n3:typAkce
n10:EUR
n3:zahajeniAkce
2007-03-28+02:00
s:numberOfPages
1
n17:hasPublisher
Mind and Health, civil association
n5:isbn
978-80-969663-2-5
n8:organizacniJednotka
14110