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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F06%3A00031735%21RIV10-MSM-14110___
rdf:type
skos:Concept n17:Vysledek
dcterms:description
Phenylethanolamine N-methyltransferase (PNMT) is a final enzyme in catecholamine synthesizing cascade that converts noradrenaline to adrenaline. Although most profuse in adrenal medulla, PNMT is expressed also in the heart, particularly in cardiac atria and ventricles. In atria, the PNMT mRNA is much more abundant compared to ventricles. In this work we aimed to find out, whether there is difference in modulation of the PNMT gene expression in cardiac atria and ventricles. We used three methodological approaches - cold as a model of mild stress, hypoxia as a model of cardiac ischemic injury and transgenic rats with incorporated mouse renin gene [TGR (mREN-2)27], to determine involvement of renin-angiotensin pathway in the PNMT gene expression. We have found that PNMT gene expression was modulated differently in cardiac atria and ventricles. In atria PNMT mRNA levels were increased by hypoxia, while cold stress decreased PNMT mRNA levels. Phenylethanolamine N-methyltransferase (PNMT) is a final enzyme in catecholamine synthesizing cascade that converts noradrenaline to adrenaline. Although most profuse in adrenal medulla, PNMT is expressed also in the heart, particularly in cardiac atria and ventricles. In atria, the PNMT mRNA is much more abundant compared to ventricles. In this work we aimed to find out, whether there is difference in modulation of the PNMT gene expression in cardiac atria and ventricles. We used three methodological approaches - cold as a model of mild stress, hypoxia as a model of cardiac ischemic injury and transgenic rats with incorporated mouse renin gene [TGR (mREN-2)27], to determine involvement of renin-angiotensin pathway in the PNMT gene expression. We have found that PNMT gene expression was modulated differently in cardiac atria and ventricles. In atria PNMT mRNA levels were increased by hypoxia, while cold stress decreased PNMT mRNA levels.
dcterms:title
Gene expression of the phenylethanolamine N-methyltransferase is differently modulated in cardiac atria and ventricles Gene expression of the phenylethanolamine N-methyltransferase is differently modulated in cardiac atria and ventricles
skos:prefLabel
Gene expression of the phenylethanolamine N-methyltransferase is differently modulated in cardiac atria and ventricles Gene expression of the phenylethanolamine N-methyltransferase is differently modulated in cardiac atria and ventricles
skos:notation
RIV/00216224:14110/06:00031735!RIV10-MSM-14110___
n3:aktivita
n13:S
n3:aktivity
S
n3:cisloPeriodika
4
n3:dodaniDat
n4:2010
n3:domaciTvurceVysledku
n14:1469517
n3:druhVysledku
n16:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
476761
n3:idVysledku
RIV/00216224:14110/06:00031735
n3:jazykVysledku
n15:eng
n3:klicovaSlova
PNMT; cardiac atria; cardiac ventricles; hypoxia; cold stress; renin
n3:klicoveSlovo
n7:hypoxia n7:renin n7:cold%20stress n7:cardiac%20ventricles n7:cardiac%20atria n7:PNMT
n3:kodStatuVydavatele
SK - Slovenská republika
n3:kontrolniKodProRIV
[811F8D8B58E3]
n3:nazevZdroje
General Physiology and Biophysics
n3:obor
n10:ED
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
8
n3:rokUplatneniVysledku
n4:2006
n3:svazekPeriodika
25
n3:tvurceVysledku
Bruderová, V. Kopáček, J. Tillinger, Andrej Květňanský, Richard Kubovčáková, Lucie Križanová, Olga Nováková, Marie Zeman, Michal
n3:wos
000244957800002
s:issn
0231-5882
s:numberOfPages
10
n6:organizacniJednotka
14110