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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F06%3A00015432%21RIV10-GA0-14110___
rdf:type
n13:Vysledek skos:Concept
dcterms:description
Haloperidol induced a decrease of amplitude and an acceleration of apparent inactivation of transient outward potassium current (Ito), both in a voltage-dependent manner. The averaged inhibition of Ito, evaluated as a change of its time integral, was 23.0 +/- 3.2% at stimulation frequency of 0.1 Hz. As a consequence of slow recovery of Ito from the haloperidol-induced block (time constant 1482 +/- 83 ms), a cumulation of the block up to about 40% appeared at 3.3 Hz. Haloperidol induced a decrease of amplitude and an acceleration of apparent inactivation of transient outward potassium current (Ito), both in a voltage-dependent manner. The averaged inhibition of Ito, evaluated as a change of its time integral, was 23.0 +/- 3.2% at stimulation frequency of 0.1 Hz. As a consequence of slow recovery of Ito from the haloperidol-induced block (time constant 1482 +/- 83 ms), a cumulation of the block up to about 40% appeared at 3.3 Hz.
dcterms:title
Effect of haloperidol on transient outward potassium current in rat ventricular myocytes Effect of haloperidol on transient outward potassium current in rat ventricular myocytes
skos:prefLabel
Effect of haloperidol on transient outward potassium current in rat ventricular myocytes Effect of haloperidol on transient outward potassium current in rat ventricular myocytes
skos:notation
RIV/00216224:14110/06:00015432!RIV10-GA0-14110___
n4:aktivita
n14:P n14:Z
n4:aktivity
P(GA305/04/1385), Z(AV0Z20760514), Z(MSM0021622402)
n4:cisloPeriodika
1-3
n4:dodaniDat
n9:2010
n4:domaciTvurceVysledku
n8:1469517 n8:7511671 n8:1457160 n8:8165459
n4:druhVysledku
n17:J
n4:duvernostUdaju
n18:S
n4:entitaPredkladatele
n19:predkladatel
n4:idSjednocenehoVysledku
473068
n4:idVysledku
RIV/00216224:14110/06:00015432
n4:jazykVysledku
n10:eng
n4:klicovaSlova
haloperidol; transient outward current; sigma receptors; rat ventricular myocytes; whole-cell pach clamp; quantitative model
n4:klicoveSlovo
n5:whole-cell%20pach%20clamp n5:haloperidol n5:sigma%20receptors n5:quantitative%20model n5:rat%20ventricular%20myocytes n5:transient%20outward%20current
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[3374E2247016]
n4:nazevZdroje
European Journal of Pharmacology
n4:obor
n16:ED
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
4
n4:projekt
n12:GA305%2F04%2F1385
n4:rokUplatneniVysledku
n9:2006
n4:svazekPeriodika
550
n4:tvurceVysledku
Nováková, Marie Pásek, Michal Matejovič, Peter Bébarová, Markéta
n4:wos
000241790800003
n4:zamer
n7:AV0Z20760514 n7:MSM0021622402
s:issn
0014-2999
s:numberOfPages
9
n15:organizacniJednotka
14110