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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F05%3A00013213%21RIV10-MZ0-14110___
rdf:type
skos:Concept n6:Vysledek
dcterms:description
The genus Treponema contains a number of disease-causing species. This includes T. pallidum pallidum (syphilis), T. pallidum pertenue (yaws), and T. pallidum endemicum (endemic syphilis, bejel) as well as T. carateum (pinta), T. paraluiscuniculi (rabbit treponematosis), and T. denticola (associated with periodontal disease). Many of these organisms differ from each other in only a few percent of their sequence, as judged by older hybridization studies, yet cause distinct diseases and pathologies. It is likely that the genetic bases for these pnenotypic differences results from subtle changes, possibly single base changes, rather than gain or loss of blocks of genes. Our aim has been to catalog genomic differences between these organisms as a starting point to pinpointing the genetic differences responsible for the infection phenotypes. We have sequenced several of these bacteria, using conventional as well as new methods, and have also performed genome wide comparisons by fingerprinting methods. The genus Treponema contains a number of disease-causing species. This includes T. pallidum pallidum (syphilis), T. pallidum pertenue (yaws), and T. pallidum endemicum (endemic syphilis, bejel) as well as T. carateum (pinta), T. paraluiscuniculi (rabbit treponematosis), and T. denticola (associated with periodontal disease). Many of these organisms differ from each other in only a few percent of their sequence, as judged by older hybridization studies, yet cause distinct diseases and pathologies. It is likely that the genetic bases for these pnenotypic differences results from subtle changes, possibly single base changes, rather than gain or loss of blocks of genes. Our aim has been to catalog genomic differences between these organisms as a starting point to pinpointing the genetic differences responsible for the infection phenotypes. We have sequenced several of these bacteria, using conventional as well as new methods, and have also performed genome wide comparisons by fingerprinting methods.
dcterms:title
Genomics of Treponema. Genomics of Treponema.
skos:prefLabel
Genomics of Treponema. Genomics of Treponema.
skos:notation
RIV/00216224:14110/05:00013213!RIV10-MZ0-14110___
n4:aktivita
n13:P n13:Z
n4:aktivity
P(GA310/04/0021), P(NI7351), Z(MSM0021622415)
n4:dodaniDat
n8:2010
n4:domaciTvurceVysledku
n12:4942558 n12:9995307
n4:druhVysledku
n11:O
n4:duvernostUdaju
n16:S
n4:entitaPredkladatele
n14:predkladatel
n4:idSjednocenehoVysledku
522608
n4:idVysledku
RIV/00216224:14110/05:00013213
n4:jazykVysledku
n10:eng
n4:klicovaSlova
T. pallidum pallidum; T. pallidum pertenue; T. pallidum endemicum; T. carateum
n4:klicoveSlovo
n7:T.%20carateum n7:T.%20pallidum%20endemicum n7:T.%20pallidum%20pallidum n7:T.%20pallidum%20pertenue
n4:kontrolniKodProRIV
[AD2BB37FD1A4]
n4:obor
n5:EB
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
7
n4:projekt
n17:NI7351 n17:GA310%2F04%2F0021
n4:rokUplatneniVysledku
n8:2005
n4:tvurceVysledku
Pospíšilová, Petra Weinstock, G. M. Norris, S. J. Palzkill, T. Albert, T. J. Sodergren, E. Šmajs, David
n4:zamer
n15:MSM0021622415
n18:organizacniJednotka
14110