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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F05%3A00012716%21RIV06-GA0-14110___
rdf:type
n13:Vysledek skos:Concept
dcterms:description
Atopy is a generally considered to be caused by interaction of genetic and environmental factors. The gene encoding CD14 is a positional candidate gene for atopy, as it is localized on chromosome 5q31.1, a region that has been linked to asthma and atopic responses. We investigated relationship among atopic phenotypes and the 1341G/T polymorphism in exon of the CD14 gene in the Czech population. Polymerase chain reaction with RFLP analyses were used to determine the CD14 genotypes in subjects with IgE-mediated allergic diseases (n = 290) and random controls (n = 189). IgE-mediated allergy was recognised by specific IgE or a positive skin prick test to any one or more allergens. The CD14 allele or genotype distributions were similar in patients and control group. However, when atopic patients were subdivided in subjects with positive and those with negative skin prick tests, this polymorphism was significantly associated with a positive reactivity to the mites. T allele of the 1341G/T polymorphism were Atopy is a generally considered to be caused by interaction of genetic and environmental factors. The gene encoding CD14 is a positional candidate gene for atopy, as it is localized on chromosome 5q31.1, a region that has been linked to asthma and atopic responses. We investigated relationship among atopic phenotypes and the 1341G/T polymorphism in exon of the CD14 gene in the Czech population. Polymerase chain reaction with RFLP analyses were used to determine the CD14 genotypes in subjects with IgE-mediated allergic diseases (n = 290) and random controls (n = 189). IgE-mediated allergy was recognised by specific IgE or a positive skin prick test to any one or more allergens. The CD14 allele or genotype distributions were similar in patients and control group. However, when atopic patients were subdivided in subjects with positive and those with negative skin prick tests, this polymorphism was significantly associated with a positive reactivity to the mites. T allele of the 1341G/T polymorphism were Gen kódující CD14 receptor je kandidátním genem pro atopii vzhledem ke své poloze na chromozomu 5q. V této studii byla nalezena asociace 1341G/T polymorfizmu v CD14 genu s atopickým fenotypem v české populaci.
dcterms:title
A polymorphism in exon of the CD14 gene and atopic phenotypes in Czech young patients with IgE-mediated allergy A polymorphism in exon of the CD14 gene and atopic phenotypes in Czech young patients with IgE-mediated allergy Polymorfizmus v exonu genu pro CD14 receptor u mladých atopických pacientů v české populaci
skos:prefLabel
A polymorphism in exon of the CD14 gene and atopic phenotypes in Czech young patients with IgE-mediated allergy Polymorfizmus v exonu genu pro CD14 receptor u mladých atopických pacientů v české populaci A polymorphism in exon of the CD14 gene and atopic phenotypes in Czech young patients with IgE-mediated allergy
skos:notation
RIV/00216224:14110/05:00012716!RIV06-GA0-14110___
n3:strany
74-74
n3:aktivita
n5:P
n3:aktivity
P(GP310/03/D193)
n3:dodaniDat
n14:2006
n3:domaciTvurceVysledku
n10:1379097 n10:8430322 n10:6918115
n3:druhVysledku
n12:D
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
511026
n3:idVysledku
RIV/00216224:14110/05:00012716
n3:jazykVysledku
n11:eng
n3:klicovaSlova
CD14; gene; polymorphism; IgE; allergy
n3:klicoveSlovo
n6:IgE n6:polymorphism n6:gene n6:allergy n6:CD14
n3:kontrolniKodProRIV
[26FD4878BE49]
n3:mistoKonaniAkce
Athens, Greece
n3:mistoVydani
Moscow, Russia
n3:nazevZdroje
International Journal on Immunorehabilitation
n3:obor
n17:EC
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:projekt
n20:GP310%2F03%2FD193
n3:rokUplatneniVysledku
n14:2005
n3:tvurceVysledku
Bučková, Dana Izakovičová-Hollá, Lydie Znojil, Vladimír
n3:typAkce
n19:WRD
n3:zahajeniAkce
2005-01-01+01:00
s:issn
1562-3629
s:numberOfPages
1
n15:hasPublisher
III European Asthma Congress
n7:organizacniJednotka
14110