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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F05%3A00012573%21RIV10-GA0-14110___
rdf:type
n17:Vysledek skos:Concept
dcterms:description
The P19 mouse embryonal carcinoma cell line was used as a model for a study of apoptosis accompanying differentiation induced by all-trans retinoic acid (ATRA). Apoptosis was detected both on the basis of morphological features (nuclear fragmentation, blebbing of plasma membrane, and formation of apoptotic bodies), and by using DNA electrophoresis and flow-cytometric measurement of DNA content. Actin cytoskeleton was studied both on morphological and submicroscopic levels. ATRA-treated cells manifested apoptosis-specific changes in the distribution of actin foremost in association with their entry into executive phase of apoptosis, when F-actin cables participated in cell disintegration into apoptotic bodies. Using immunogold labeling, actin was also identified in centers of fragmenting apoptotic nuclei, in the disintegration of which it is likely involved as well. At the same time, a cleavage of actin by active caspase-3 was proved, resulting in the emergence of 32kDa fragment termed fractin. The P19 mouse embryonal carcinoma cell line was used as a model for a study of apoptosis accompanying differentiation induced by all-trans retinoic acid (ATRA). Apoptosis was detected both on the basis of morphological features (nuclear fragmentation, blebbing of plasma membrane, and formation of apoptotic bodies), and by using DNA electrophoresis and flow-cytometric measurement of DNA content. Actin cytoskeleton was studied both on morphological and submicroscopic levels. ATRA-treated cells manifested apoptosis-specific changes in the distribution of actin foremost in association with their entry into executive phase of apoptosis, when F-actin cables participated in cell disintegration into apoptotic bodies. Using immunogold labeling, actin was also identified in centers of fragmenting apoptotic nuclei, in the disintegration of which it is likely involved as well. At the same time, a cleavage of actin by active caspase-3 was proved, resulting in the emergence of 32kDa fragment termed fractin.
dcterms:title
The role of actin in the apoptotic cell death of P19 embryonal carcinoma cells. The role of actin in the apoptotic cell death of P19 embryonal carcinoma cells.
skos:prefLabel
The role of actin in the apoptotic cell death of P19 embryonal carcinoma cells. The role of actin in the apoptotic cell death of P19 embryonal carcinoma cells.
skos:notation
RIV/00216224:14110/05:00012573!RIV10-GA0-14110___
n3:aktivita
n8:P
n3:aktivity
P(GA304/00/0403)
n3:cisloPeriodika
4
n3:dodaniDat
n6:2010
n3:domaciTvurceVysledku
n11:1195271 n11:6317804 n11:9637915
n3:druhVysledku
n9:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
541388
n3:idVysledku
RIV/00216224:14110/05:00012573
n3:jazykVysledku
n18:eng
n3:klicovaSlova
apoptosis; actin cytoskeleton; fractin; caspase-3; all-trans retinoic acid; cell differentiation
n3:klicoveSlovo
n4:actin%20cytoskeleton n4:fractin n4:caspase-3 n4:cell%20differentiation n4:all-trans%20retinoic%20acid n4:apoptosis
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[7B79E974B84D]
n3:nazevZdroje
International Journal of Oncology
n3:obor
n5:EA
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:projekt
n7:GA304%2F00%2F0403
n3:rokUplatneniVysledku
n6:2005
n3:svazekPeriodika
27
n3:tvurceVysledku
Svoboda, Augustin Veselská, Renata Neradil, Jakub
s:issn
1019-6439
s:numberOfPages
10
n16:organizacniJednotka
14110