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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F04%3A00010731%21RIV08-MSM-14110___
rdf:type
skos:Concept n14:Vysledek
dcterms:description
Cílem experimentu bylo popsat vliv standardizovaného extraktu LI 160 na metabolickou aktivitu CYP2D1/2 na modelu izolovaných perfundovaných jater. Cílem experimentu bylo popsat vliv standardizovaného extraktu LI 160 na metabolickou aktivitu CYP2D1/2 na modelu izolovaných perfundovaných jater. St. Johns wort (Hypericum perforatum) is a popular over-the-counter dietary supplement and a herbal antidepressant that has been implicated in drug interactions with substrates of several cytochrome P450 (CYP) isozymes. The effects of the St. Johns wort extract (100 mg/kg, i.p., once daily for 10 days) on metabolic activity of CYP450 was assessed in the system of isolated perfused rat liver. The substrates used in this study were tolbutamide (CYP2C6), dextromethorphan (CYP2D2) and midazolam (CYP3A2). Validated HPLC method was used to quantify all compounds of interest. St. Johns wort administration affected CYP activity, caused a significant decline in AUC of dextromethorphan [F(4,31)=1511, p<0.001; PLSD, p<0.001] and AUC of midazolam [F(3,25)=221, p<0.001; PLSD, p=0.035] and a significant increase in AUC of tolbutamide [F(3,26)=200, p<0.001; PLSD, p<0.001]. St. Johns wort administration resulted in a significant induction of CYP2D2 and CYP3A2, and in a significant inhibition of CYP2C6
dcterms:title
Effect of standardized extract LI 160 (Hypericum perforatum) on metabolic activity of CYP-450 CYP1A2, CYP2C6, CYP2D2 and CYP3A1/2 in preclinical experiment. Vliv standardizovaného extraktu LI 160 (Hypericum perforatum) na metabolickou aktivitu cytochromu P-450 CYP1A2, CYP2C6, CYP2D2 a CYP3A1/2 v preklinickém experimentu. Vliv standardizovaného extraktu LI 160 (Hypericum perforatum) na metabolickou aktivitu cytochromu P-450 CYP1A2, CYP2C6, CYP2D2 a CYP3A1/2 v preklinickém experimentu.
skos:prefLabel
Effect of standardized extract LI 160 (Hypericum perforatum) on metabolic activity of CYP-450 CYP1A2, CYP2C6, CYP2D2 and CYP3A1/2 in preclinical experiment. Vliv standardizovaného extraktu LI 160 (Hypericum perforatum) na metabolickou aktivitu cytochromu P-450 CYP1A2, CYP2C6, CYP2D2 a CYP3A1/2 v preklinickém experimentu. Vliv standardizovaného extraktu LI 160 (Hypericum perforatum) na metabolickou aktivitu cytochromu P-450 CYP1A2, CYP2C6, CYP2D2 a CYP3A1/2 v preklinickém experimentu.
skos:notation
RIV/00216224:14110/04:00010731!RIV08-MSM-14110___
n3:strany
9-9
n3:aktivita
n15:Z
n3:aktivity
Z(MSM 141100001)
n3:dodaniDat
n13:2008
n3:domaciTvurceVysledku
n16:3648753 n16:6157181 n16:3007251 n16:8110549 n16:1309137 n16:5767628
n3:druhVysledku
n4:D
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
592996
n3:idVysledku
RIV/00216224:14110/04:00010731
n3:jazykVysledku
n9:cze
n3:klicovaSlova
St Johns wort; CYP-450
n3:klicoveSlovo
n12:CYP-450 n12:St%20Johns%20wort
n3:kontrolniKodProRIV
[B005EDF8E514]
n3:mistoKonaniAkce
Brno
n3:mistoVydani
Brno
n3:nazevZdroje
In MediFórum.
n3:obor
n18:FR
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
7
n3:rokUplatneniVysledku
n13:2004
n3:tvurceVysledku
McCaskey Hadašová, Eva Šulcová, Alexandra Dostálek, Miroslav Pistovčáková, Jana Linhart, Igor Tomandl, Josef Juřica, Jan
n3:typAkce
n20:CST
n3:zahajeniAkce
2004-01-01+01:00
n3:zamer
n10:MSM%20141100001
s:numberOfPages
1
n19:hasPublisher
Kongresové centrum Brno, a.s.,
n7:isbn
80-86607-13-5
n5:organizacniJednotka
14110