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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F04%3A00010248%21RIV08-MSM-14110___
rdf:type
skos:Concept n10:Vysledek
dcterms:description
The phenomenon of sensitization enhancing usually stimulant behavioral response to repeatedly administered drugs of abuse has been described both in laboratory animals and human beings. There is also data available confirming a cross-sensitization between different types of drugs of abuse supporting further the hypothesis that repeated use of one drug of abuse may facilitate the consumption of other drugs. Previously we confirmed the sensitization to methamphetamine (MET) stimulatory effect on locomotor/exploratory behavior, and also to its inhibitory influence on aggression in mice. Furthermore, such sensitization was present in mice cross-sensitized with cannabinoid methanandamide (CAN). Our experiences with behavioral as well as immunological profiles of different cannabinoids received in our collaborative studies with Israel colleagues (Mechoulam R., Fride E.) gave rise to the present study comparing cross-sensitization with CAN to behavioral MET effects with their influences on immune function of The phenomenon of sensitization enhancing usually stimulant behavioral response to repeatedly administered drugs of abuse has been described both in laboratory animals and human beings. There is also data available confirming a cross-sensitization between different types of drugs of abuse supporting further the hypothesis that repeated use of one drug of abuse may facilitate the consumption of other drugs. Previously we confirmed the sensitization to methamphetamine (MET) stimulatory effect on locomotor/exploratory behavior, and also to its inhibitory influence on aggression in mice. Furthermore, such sensitization was present in mice cross-sensitized with cannabinoid methanandamide (CAN). Our experiences with behavioral as well as immunological profiles of different cannabinoids received in our collaborative studies with Israel colleagues (Mechoulam R., Fride E.) gave rise to the present study comparing cross-sensitization with CAN to behavioral MET effects with their influences on immune function of Byly potvrzeny funkční interakce mezi endokanabinboidním systémem a farmakologickými mechanismy metamfetaminu v obou studovaných parametrech.
dcterms:title
Interaction of cannabinoid methanandamide with processes of sensitization to both behavioral and immunological methamphetamine effects in mice. Interaction of cannabinoid methanandamide with processes of sensitization to both behavioral and immunological methamphetamine effects in mice. Interakce kanabinoidu metanandamidu s procesy sensitizace k behaviorálním a imunologickým účinklům metamfetaminu u myší
skos:prefLabel
Interaction of cannabinoid methanandamide with processes of sensitization to both behavioral and immunological methamphetamine effects in mice. Interakce kanabinoidu metanandamidu s procesy sensitizace k behaviorálním a imunologickým účinklům metamfetaminu u myší Interaction of cannabinoid methanandamide with processes of sensitization to both behavioral and immunological methamphetamine effects in mice.
skos:notation
RIV/00216224:14110/04:00010248!RIV08-MSM-14110___
n3:strany
90
n3:aktivita
n4:Z
n3:aktivity
Z(MSM 141100001)
n3:dodaniDat
n11:2008
n3:domaciTvurceVysledku
n12:8841144 n12:3007251
n3:druhVysledku
n18:D
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
568544
n3:idVysledku
RIV/00216224:14110/04:00010248
n3:jazykVysledku
n15:eng
n3:klicovaSlova
methanandamide; methamphetamine; sensitization; mice
n3:klicoveSlovo
n6:sensitization n6:methanandamide n6:mice n6:methamphetamine
n3:kontrolniKodProRIV
[57E5C1D79489]
n3:mistoKonaniAkce
San Juan, Puerto Rico
n3:mistoVydani
USA
n3:nazevZdroje
Abstracts - NIDA International Forum 2004, San Juan, Puerto Rico
n3:obor
n14:FR
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:rokUplatneniVysledku
n11:2004
n3:tvurceVysledku
Landa, Leoš Šulcová, Alexandra
n3:typAkce
n17:WRD
n3:zahajeniAkce
2004-01-01+01:00
n3:zamer
n16:MSM%20141100001
s:numberOfPages
1
n20:hasPublisher
US National Institute on Drug Abuse
n8:organizacniJednotka
14110