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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F04%3A00010247%21RIV08-MSM-14110___
rdf:type
skos:Concept n17:Vysledek
rdfs:seeAlso
CD - FENS Forum 2004
dcterms:description
Impact of cannabinoid CB2 receptor activity on aggressive behavior in mice and sensitization to methamphetamine antiaggresive effects. Cannabinoid receptor CB2 is localized mainly outside of the CNS. Thus a poor impact of its activity on behavior can be expected. Previously we found development of both sensitization to methamphetamine (MET) antiaggressive effects by pre-treatment with repeated MET doses and a cross-sensitization to this MET effect with cannabinoid CB1 receptor agonist methanandamide in the model of agonistic behaviour in singly-housed male mice on paired interactions with non-aggressive group-housed partners. This supported the evidence of interaction between the endocannabinoid system and MET brain mechanism. The aim of the present study was to investigate whether the CB2 receptor activity might also be involved in regulation of mouse agonistic behaviour, and in development of sensitivity to methamphetamine. Therefore the CB2 receptor agonist JWH 015 (JWH) has been tested using ident Impact of cannabinoid CB2 receptor activity on aggressive behavior in mice and sensitization to methamphetamine antiaggresive effects. Cannabinoid receptor CB2 is localized mainly outside of the CNS. Thus a poor impact of its activity on behavior can be expected. Previously we found development of both sensitization to methamphetamine (MET) antiaggressive effects by pre-treatment with repeated MET doses and a cross-sensitization to this MET effect with cannabinoid CB1 receptor agonist methanandamide in the model of agonistic behaviour in singly-housed male mice on paired interactions with non-aggressive group-housed partners. This supported the evidence of interaction between the endocannabinoid system and MET brain mechanism. The aim of the present study was to investigate whether the CB2 receptor activity might also be involved in regulation of mouse agonistic behaviour, and in development of sensitivity to methamphetamine. Therefore the CB2 receptor agonist JWH 015 (JWH) has been tested using ident Na rozdíl od dříve prezentovaných výsledků sledujících stejné vzatahy při farmakologikcém ovlivňování kanabinoidních receptorů CB1,stimulace CB2 receptorů nevedla ke krossensitizaci k antiagresivním účinkům metamfetaminu.
dcterms:title
Impact of cannabinoid CB2 receptor activity on aggressive behaviour in mice and senistization to methamphetamine antiaggressive effects. Impact of cannabinoid CB2 receptor activity on aggressive behaviour in mice and senistization to methamphetamine antiaggressive effects. Vliv aktivity kanabinoidních receptorů CB2 na agresivitu u myší a sensitizacei k antiagresivnímu účinku metamfetaminu
skos:prefLabel
Vliv aktivity kanabinoidních receptorů CB2 na agresivitu u myší a sensitizacei k antiagresivnímu účinku metamfetaminu Impact of cannabinoid CB2 receptor activity on aggressive behaviour in mice and senistization to methamphetamine antiaggressive effects. Impact of cannabinoid CB2 receptor activity on aggressive behaviour in mice and senistization to methamphetamine antiaggressive effects.
skos:notation
RIV/00216224:14110/04:00010247!RIV08-MSM-14110___
n4:aktivita
n12:Z
n4:aktivity
Z(MSM 141100001)
n4:dodaniDat
n6:2008
n4:domaciTvurceVysledku
n11:3007251 n11:8841144 n11:3395197
n4:druhVysledku
n18:A
n4:duvernostUdaju
n9:S
n4:entitaPredkladatele
n14:predkladatel
n4:idSjednocenehoVysledku
567359
n4:idVysledku
RIV/00216224:14110/04:00010247
n4:jazykVysledku
n19:eng
n4:klicovaSlova
cannabinoid CB2 receptor; methamphetamine; aggressivity; mice
n4:klicoveSlovo
n7:cannabinoid%20CB2%20receptor n7:methamphetamine n7:aggressivity n7:mice
n4:kodPristupu
n13:V
n4:kontrolniKodProRIV
[A81AE5F7DF22]
n4:mistoVydani
Portugalsko
n4:objednatelVyzkumneZpravy
FENS
n4:obor
n15:FR
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
3
n4:rokUplatneniVysledku
n6:2004
n4:tvurceVysledku
Landa, Leoš Šulcová, Alexandra Šlais, Karel
n4:verzeVyzkumneZpravy
CD - FENS Forum 2004
n4:zamer
n8:MSM%20141100001
n10:organizacniJednotka
14110