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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F04%3A00010166%21RIV08-MSM-14110___
rdf:type
n7:Vysledek skos:Concept
dcterms:description
The IL-18 gene has been suggested a susceptibility gene for allergic diseases for its important role in the balance between Th1 and Th2 immune responses. This was supported by several studies in which associations between some of the IL-18 gene polymorphisms and different atopic phenotypes were reported. In this study, we investigated an association of IgE-mediated allergic diseases in the Czech population and -133C/G single nucleotide polymorphism in the IL-18 gene promoter 2 which was previously associated with high IgE levels and specific sensitization in one study. IL-18 gen byl označen jako možný gen pro alergické nemoci vzhledem k jeho důležité úloze při udržování rovnováhy mezi Th1 a Th2 imunitní odpovědí. Některé práce našly asociaci mezi vybranými polymorfizmy v genu pro IL-18 a různými atopickými fenotypy. V naší práci jsme analyzovali asociaci IgE zprostředkovaných alergických stavů v české populaci s -133C/G jednonukleotidovou záměnou v promotoru genu pro IL_18, která byla v dřívější studii asociována s vyššími hladinami IgE a specifickou senzitizací. The IL-18 gene has been suggested a susceptibility gene for allergic diseases for its important role in the balance between Th1 and Th2 immune responses. This was supported by several studies in which associations between some of the IL-18 gene polymorphisms and different atopic phenotypes were reported. In this study, we investigated an association of IgE-mediated allergic diseases in the Czech population and -133C/G single nucleotide polymorphism in the IL-18 gene promoter 2 which was previously associated with high IgE levels and specific sensitization in one study.
dcterms:title
IL-18 gene promoter 2 polymorphism and IgE-mediated allergy in Czech population IL-18 gene promoter 2 polymorphism and IgE-mediated allergy in Czech population Dva polymorfizmy v promotoru genu pro IL-18 a IgE zprostředkovaná alergie v české populaci
skos:prefLabel
IL-18 gene promoter 2 polymorphism and IgE-mediated allergy in Czech population Dva polymorfizmy v promotoru genu pro IL-18 a IgE zprostředkovaná alergie v české populaci IL-18 gene promoter 2 polymorphism and IgE-mediated allergy in Czech population
skos:notation
RIV/00216224:14110/04:00010166!RIV08-MSM-14110___
n3:strany
130-130
n3:aktivita
n21:Z
n3:aktivity
Z(MSM 141100002)
n3:dodaniDat
n12:2008
n3:domaciTvurceVysledku
n9:1379097 n9:2272792 n9:1993038 n9:1730908 n9:6918115
n3:druhVysledku
n8:D
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
567269
n3:idVysledku
RIV/00216224:14110/04:00010166
n3:jazykVysledku
n10:eng
n3:klicovaSlova
IL-18; gene; polymorphism; IgE; allergy
n3:klicoveSlovo
n16:IgE n16:polymorphism n16:allergy n16:IL-18 n16:gene
n3:kontrolniKodProRIV
[AE5FDCBBD4F9]
n3:mistoKonaniAkce
Amsterodam, the Netherlands
n3:mistoVydani
Stockholm, Sweden
n3:nazevZdroje
Abstract Book
n3:obor
n17:EC
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:rokUplatneniVysledku
n12:2004
n3:tvurceVysledku
Schüller, Marcel Izakovičová-Hollá, Lydie Šebelová, Šárka Bučková, Dana Vácha, Jiří
n3:typAkce
n11:WRD
n3:zahajeniAkce
2004-01-01+01:00
n3:zamer
n14:MSM%20141100002
s:numberOfPages
1
n13:hasPublisher
European Academy of Allergology and Clinical Immunology
n20:isbn
3-9808961-3-7
n18:organizacniJednotka
14110