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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F04%3A00010158%21RIV09-GA0-14110___
rdf:type
n4:Vysledek skos:Concept
dcterms:description
Background and aims: Set association of selected genetic polymorphisms (40 single nucleotide polymorphisms (SNPs)) in 26 candidate genes on chromosomes 1, 3, 4, 6, 7, 12, 16, 17, 19, 20 and 22 with diabetic nephropathy (DN) was studied in patients with type 2 diabetes mellitus. Products of genes studied were components of renin-angiotensin system, other haemodynamic factors, antioxidant enzymes, cytokines and growth factors, AGE-receptors, extracellular matrix remodelation enzymes and others. Materials and methods: A total of 650 unrelated Caucasian subjects were enrolled into study comprising three groups: diabetics with parallel DN (cases), diabetics without DN (controls 1) and non-diabetics (controls 2). DN diagnosis was based on assessment of albumin excretion rate (AER). Genotypes were detected by means of PCR-based methodology. Set association study was performed to find SNPs jointly associated with disease. Results: An initial comparison of genotype frequencies in case and pooled control indivi Background and aims: Set association of selected genetic polymorphisms (40 single nucleotide polymorphisms (SNPs)) in 26 candidate genes on chromosomes 1, 3, 4, 6, 7, 12, 16, 17, 19, 20 and 22 with diabetic nephropathy (DN) was studied in patients with type 2 diabetes mellitus. Products of genes studied were components of renin-angiotensin system, other haemodynamic factors, antioxidant enzymes, cytokines and growth factors, AGE-receptors, extracellular matrix remodelation enzymes and others. Materials and methods: A total of 650 unrelated Caucasian subjects were enrolled into study comprising three groups: diabetics with parallel DN (cases), diabetics without DN (controls 1) and non-diabetics (controls 2). DN diagnosis was based on assessment of albumin excretion rate (AER). Genotypes were detected by means of PCR-based methodology. Set association study was performed to find SNPs jointly associated with disease. Results: An initial comparison of genotype frequencies in case and pooled control indivi Predbezne vysledky naznacuji, ze vybrane polymorfizmy v genech kodujicich AGE-receptory, antioxidacni enzymy a cytokiny funguji jako rizikove faktory diabeticke nefropatie.
dcterms:title
Multilokusovy pristup k identifikaci genetickych rizikovych faktoru diabeticke nefropatie u diabetu 2. typu Multilocus approach to the identification of genetic risk factors for diabetic nephropathy in type 2 diabetes Multilocus approach to the identification of genetic risk factors for diabetic nephropathy in type 2 diabetes
skos:prefLabel
Multilocus approach to the identification of genetic risk factors for diabetic nephropathy in type 2 diabetes Multilokusovy pristup k identifikaci genetickych rizikovych faktoru diabeticke nefropatie u diabetu 2. typu Multilocus approach to the identification of genetic risk factors for diabetic nephropathy in type 2 diabetes
skos:notation
RIV/00216224:14110/04:00010158!RIV09-GA0-14110___
n3:aktivita
n13:P n13:Z
n3:aktivity
P(GP303/02/D127), Z(MSM 141100002)
n3:cisloPeriodika
Suppl 1
n3:dodaniDat
n17:2009
n3:domaciTvurceVysledku
n11:7988788 n11:5105374 n11:6108768
n3:druhVysledku
n9:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
575007
n3:idVysledku
RIV/00216224:14110/04:00010158
n3:jazykVysledku
n15:eng
n3:klicovaSlova
diabetes; polymorphisms; diabetic nephropathy
n3:klicoveSlovo
n10:polymorphisms n10:diabetes n10:diabetic%20nephropathy
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[052F66C6F22B]
n3:nazevZdroje
Diabetologia
n3:obor
n16:FB
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
5
n3:projekt
n5:GP303%2F02%2FD127
n3:rokUplatneniVysledku
n17:2004
n3:svazekPeriodika
47
n3:tvurceVysledku
Hertlová, Miluše Kaňková, Kateřina Krusová, Darja Ott, Jurg Schwenke, Susanne
n3:wos
000223951600126
n3:zamer
n7:MSM%20141100002
s:issn
0012-186X
s:numberOfPages
1
n14:organizacniJednotka
14110