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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F03%3A00009856%21RIV09-MSM-14110___
rdf:type
n13:Vysledek skos:Concept
dcterms:description
%22Low-density lipoprotein receptor-related protein 1%22 (LRP1) je multifunkční endocytický receptor s důležitou rolí při regulaci aktivity proteáz v extracelulární matrix. Několik studií popsalo také jeho roli ve vnitrobuněčné signalizaci. Bylo prokázáno, že exprese LRP1 má vztah k invazivitě nádorových buněk. Podle nedávných zjištění se však LRP1 může podílet také na nádorové transformaci buněk. V naší práci jsme studovali asociaci mezi genovým polymorfizmem C766T ve třetím exonu genu pro LRP1 a karcinomem prsu na vzorku žen indoevropské rasy. Alelické a genotypové frekvence sledovaného polymorfizmu byly určeny u 164 žen s karcinomem prsu a u 183 věkově odpovídajících kontrol. Mezi ženami s karcinomem prsu byla pozorována větší četnost alely T sledovaného polymorfizmu v porovnání s kontrolní populací (0.21 versus 0.15, P=0.01963). Bylo pozorováno také signifikantně větší zastoupení nositelek alespoň jedné T alely (homozygotů a heterozygotů) mezi pacientkami s karcinomem prsu (poměr šancí 1.743, 95% inte Background: Low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional endocytic receptor with an important role in regulating the activity of proteinases in extracellular matrix. Several studies have also described its role in intracellular signaling. Previous studies showed that the expression of LRP1 is related to invasiveness of cancer cells. However, recent data on LRP1 suggest that this receptor can also be involved in tumor establishment and progression. Methods: We investigated an association between the C766T polymorphism of the third exon of the LRP1 gene and breast cancer in a sample of women of Caucasian origin. Allele and genotype frequencies of this polymorphism were assessed in 164 women with breast cancer and in 183 age-compatible women without a history of any cancer disease. Results: An increase in LRP1 T allele frequency in subjects with breast cancer was observed compared with controls (0.21 versus 0.15, P=0.01963). A significant excess of genotypes with the T a Background: Low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional endocytic receptor with an important role in regulating the activity of proteinases in extracellular matrix. Several studies have also described its role in intracellular signaling. Previous studies showed that the expression of LRP1 is related to invasiveness of cancer cells. However, recent data on LRP1 suggest that this receptor can also be involved in tumor establishment and progression. Methods: We investigated an association between the C766T polymorphism of the third exon of the LRP1 gene and breast cancer in a sample of women of Caucasian origin. Allele and genotype frequencies of this polymorphism were assessed in 164 women with breast cancer and in 183 age-compatible women without a history of any cancer disease. Results: An increase in LRP1 T allele frequency in subjects with breast cancer was observed compared with controls (0.21 versus 0.15, P=0.01963). A significant excess of genotypes with the T a
dcterms:title
C766T low-density lipoprotein receptor-related protein 1 ( LRP1) gene polymorphism and susceptibility to breast cancer Genový polymorfismus C766T v genu pro low-density lipoprotein receptor-related protein 1 ( LRP1) a náchylnost ke karcinomu prsu C766T low-density lipoprotein receptor-related protein 1 ( LRP1) gene polymorphism and susceptibility to breast cancer
skos:prefLabel
C766T low-density lipoprotein receptor-related protein 1 ( LRP1) gene polymorphism and susceptibility to breast cancer Genový polymorfismus C766T v genu pro low-density lipoprotein receptor-related protein 1 ( LRP1) a náchylnost ke karcinomu prsu C766T low-density lipoprotein receptor-related protein 1 ( LRP1) gene polymorphism and susceptibility to breast cancer
skos:notation
RIV/00216224:14110/03:00009856!RIV09-MSM-14110___
n3:aktivita
n11:Z
n3:aktivity
Z(MSM 141100002)
n3:cisloPeriodika
3
n3:dodaniDat
n4:2009
n3:domaciTvurceVysledku
n5:5969050 n5:6918115 n5:4648137 n5:1730908 n5:6234348
n3:druhVysledku
n18:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
602674
n3:idVysledku
RIV/00216224:14110/03:00009856
n3:jazykVysledku
n15:eng
n3:klicovaSlova
breast cancer; case-control study; genetic polymorphism; low-density lipoprotein receptor-related protein 1
n3:klicoveSlovo
n9:case-control%20study n9:genetic%20polymorphism n9:breast%20cancer n9:low-density%20lipoprotein%20receptor-related%20protein%201
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[C518EEB07D5D]
n3:nazevZdroje
Breast Cancer Research
n3:obor
n14:EB
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:rokUplatneniVysledku
n4:2003
n3:svazekPeriodika
5
n3:tvurceVysledku
Beneš, Petr Vácha, Jiří Žaloudík, Jan Izakovičová-Hollá, Lydie Jurajda, Michal
n3:wos
000183439400004
n3:zamer
n17:MSM%20141100002
s:issn
1465-542X
s:numberOfPages
5
n16:organizacniJednotka
14110