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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F03%3A00009288%21RIV09-MZ0-14110___
rdf:type
n7:Vysledek skos:Concept
dcterms:description
The ventral root avulsion results in the loss of motoneurons in the corresponding spinal cord segment. In the present experiments we have tested a neuroprotective effect of Cerebrolysin and insulin-like growth factor-I (IGF-I) on survival of avulsed motoneurons after their chronic intrathecal administration in the adult rats. We have found that avulsion of the C5 ventral roots results in significant loss of motoneurons in the same spinal cord segment due mainly to apoptosis. In comparison to the untreated control rats, the amount of motoneuron survival in avulsed ventral horn was significantly higher after 4 weeks intrathecal administration of Cerebrolysin and IGF-I. No significant differences were observed between effects of Cerebrolysin and IGF-I in our experimental model. The results suggest neuroprotective effect of Cerebrolysin on survival of motoneurons following the ventral root avulsion. Avuilse ventrálního kořene spinálního nervu způsobuje ztrátu motoneuronů The ventral root avulsion results in the loss of motoneurons in the corresponding spinal cord segment. In the present experiments we have tested a neuroprotective effect of Cerebrolysin and insulin-like growth factor-I (IGF-I) on survival of avulsed motoneurons after their chronic intrathecal administration in the adult rats. We have found that avulsion of the C5 ventral roots results in significant loss of motoneurons in the same spinal cord segment due mainly to apoptosis. In comparison to the untreated control rats, the amount of motoneuron survival in avulsed ventral horn was significantly higher after 4 weeks intrathecal administration of Cerebrolysin and IGF-I. No significant differences were observed between effects of Cerebrolysin and IGF-I in our experimental model. The results suggest neuroprotective effect of Cerebrolysin on survival of motoneurons following the ventral root avulsion.
dcterms:title
Záchrana spinálních motoneuronů před smrtí způsobenou avulzí spnálních kořenů Rescue of rat spinal motoneurons from avulsion-induced cell death by intrathecal administration of IGF-I and Cerebrolysin. Rescue of rat spinal motoneurons from avulsion-induced cell death by intrathecal administration of IGF-I and Cerebrolysin.
skos:prefLabel
Záchrana spinálních motoneuronů před smrtí způsobenou avulzí spnálních kořenů Rescue of rat spinal motoneurons from avulsion-induced cell death by intrathecal administration of IGF-I and Cerebrolysin. Rescue of rat spinal motoneurons from avulsion-induced cell death by intrathecal administration of IGF-I and Cerebrolysin.
skos:notation
RIV/00216224:14110/03:00009288!RIV09-MZ0-14110___
n4:aktivita
n9:P n9:Z
n4:aktivity
P(NF6658), Z(MSM 141100001)
n4:cisloPeriodika
3
n4:dodaniDat
n13:2009
n4:domaciTvurceVysledku
n17:5568692
n4:druhVysledku
n19:J
n4:duvernostUdaju
n18:S
n4:entitaPredkladatele
n16:predkladatel
n4:idSjednocenehoVysledku
625330
n4:idVysledku
RIV/00216224:14110/03:00009288
n4:jazykVysledku
n12:eng
n4:klicovaSlova
motoneuron; promotion; neurotrophic
n4:klicoveSlovo
n5:neurotrophic n5:motoneuron n5:promotion
n4:kodStatuVydavatele
DE - Spolková republika Německo
n4:kontrolniKodProRIV
[19D4D26CA55F]
n4:nazevZdroje
Annals of Anatomy
n4:obor
n10:FH
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
4
n4:projekt
n15:NF6658
n4:rokUplatneniVysledku
n13:2003
n4:svazekPeriodika
185
n4:tvurceVysledku
Stejskal, Lubomír Dubový, Petr Haninec, Pavel Houšťava, Ladislav
n4:wos
000183351200007
n4:zamer
n14:MSM%20141100001
s:issn
0940-9602
s:numberOfPages
6
n6:organizacniJednotka
14110