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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F03%3A00009203%21RIV09-MSM-14110___
rdf:type
skos:Concept n15:Vysledek
dcterms:description
To examine potential antidepressant effects of felbamate rats with bilateral lesion of the olfactory bulb (OB rats) were used in the present study. This animal model resembles behavioural, endocrine and immune changes found in human depression. Repeated felbamate treatment (240 mg/kg, orally, for 10 days) effects on locomotor behaviour (ambulation) in an open field test, and on leukocyte phagocytosis were studied in both sham-operated and bulbectomized rats. Felbamate elicited a significant decrease of the previously hyperactive ambulation of the OB rats after 10 days of medication (240 mg/kg/day, orally), while no marked changes were observed in sham-operated animals. On the day 10 of the felbamate treatment, there was no significant difference in locomotor activity of the OB and the sham-operated rats. Significantly suppressed leukocyte phagocytic activity recorded in OB rats was disinhibited in those treated repeatedly with felbamate while the drug did not alter phagocytosis of leukocytes in sham-o To examine potential antidepressant effects of felbamate rats with bilateral lesion of the olfactory bulb (OB rats) were used in the present study. This animal model resembles behavioural, endocrine and immune changes found in human depression. Repeated felbamate treatment (240 mg/kg, orally, for 10 days) effects on locomotor behaviour (ambulation) in an open field test, and on leukocyte phagocytosis were studied in both sham-operated and bulbectomized rats. Felbamate elicited a significant decrease of the previously hyperactive ambulation of the OB rats after 10 days of medication (240 mg/kg/day, orally), while no marked changes were observed in sham-operated animals. On the day 10 of the felbamate treatment, there was no significant difference in locomotor activity of the OB and the sham-operated rats. Significantly suppressed leukocyte phagocytic activity recorded in OB rats was disinhibited in those treated repeatedly with felbamate while the drug did not alter phagocytosis of leukocytes in sham-o Model olfaktorické bulbektomie hlodavců představuje zvířecí model deprese. Ve zmíněném modelu jsme testovali účinky opakovaného podávání felbamátu (240 mg/kg, p.o., deset dnů) na lokomoční chování v testu otevřeného pole a leukocytární fagocytózu kontrolních a bulbektomovaných potkanů. Felbamát signifikantně snížil typickou motorickou hyperaktivitu bulbektomovaných potkanů, zatímco neovlivnil lokomoci kontrolních zvířat. Snížená leukocytární fagocytóza bulbektomovaných potkanů byla desinhibovaná po desetidenním podávání felbamátu. Behaviorální a imuninitní data svědčí pro potenciálně antidepresivní účinky felbamátu.
dcterms:title
Účinky felbamátu na lokomoční chování a leukocytární fagocytózu potkanů jsou podobné účinkům antidepresiv Antidepressant-like effects of felbamate on locomotor behaviour and leukocyte phagocytosis in rats Antidepressant-like effects of felbamate on locomotor behaviour and leukocyte phagocytosis in rats
skos:prefLabel
Antidepressant-like effects of felbamate on locomotor behaviour and leukocyte phagocytosis in rats Antidepressant-like effects of felbamate on locomotor behaviour and leukocyte phagocytosis in rats Účinky felbamátu na lokomoční chování a leukocytární fagocytózu potkanů jsou podobné účinkům antidepresiv
skos:notation
RIV/00216224:14110/03:00009203!RIV09-MSM-14110___
n3:aktivita
n16:Z
n3:aktivity
Z(MSM 141100001)
n3:cisloPeriodika
Suppl.4
n3:dodaniDat
n14:2009
n3:domaciTvurceVysledku
n5:6157181 n5:3007251
n3:druhVysledku
n12:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
598589
n3:idVysledku
RIV/00216224:14110/03:00009203
n3:jazykVysledku
n6:eng
n3:klicovaSlova
antiepileptic; felbamate; animal model of depression; bulbectomy
n3:klicoveSlovo
n10:bulbectomy n10:animal%20model%20of%20depression n10:felbamate n10:antiepileptic
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[917B5D15E9DE]
n3:nazevZdroje
European Neuropsychopharmacology
n3:obor
n9:FR
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:rokUplatneniVysledku
n14:2003
n3:svazekPeriodika
13
n3:tvurceVysledku
Pistovčáková, Jana Šulcová, Alexandra
n3:wos
000185412300215
n3:zamer
n18:MSM%20141100001
s:issn
0924-977X
s:numberOfPages
1
n7:organizacniJednotka
14110