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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F03%3A00008969%21RIV08-MSM-14110___
rdf:type
skos:Concept n16:Vysledek
dcterms:description
In Experiment 1, psychostimulant methamphetamine and cannabinoid receptor agonist methanandamide were injected 7 days to two groups of mice either at the doses of 2.5 mg/kg/day or 0,5 mg/kg/day. On the day 8 all mice were given a "challenge dose" of methamphetamine 2.5 mg/kg to check a development of the hypothesised sensitization. In Experiment 2, methamphetamine and combined methamphetamine+selective CB1 receptor antagonist AM 251 treatments were injected 7 days to two groups of mice at the doses of either 2.5 mg/kg/day or 5 mg/kg/day. For the same reason as in Experiment 1 "challenge doses" of methamphetamine 2.5 mg/kg were given to all mice on the day 8. In Experiment 1, it has been shown that compared to control animals this procedure elicited in both methamphetamine and methanandamide pre-treated groups behavioural sensitisation: significant increase in distance run and fast movements and a significant decrease in resting time. Conversely, in Experiment 2, while in the group In Experiment 1, psychostimulant methamphetamine and cannabinoid receptor agonist methanandamide were injected 7 days to two groups of mice either at the doses of 2.5 mg/kg/day or 0,5 mg/kg/day. On the day 8 all mice were given a "challenge dose" of methamphetamine 2.5 mg/kg to check a development of the hypothesised sensitization. In Experiment 2, methamphetamine and combined methamphetamine+selective CB1 receptor antagonist AM 251 treatments were injected 7 days to two groups of mice at the doses of either 2.5 mg/kg/day or 5 mg/kg/day. For the same reason as in Experiment 1 "challenge doses" of methamphetamine 2.5 mg/kg were given to all mice on the day 8. In Experiment 1, it has been shown that compared to control animals this procedure elicited in both methamphetamine and methanandamide pre-treated groups behavioural sensitisation: significant increase in distance run and fast movements and a significant decrease in resting time. Conversely, in Experiment 2, while in the group In Experiment 1, psychostimulant methamphetamine and cannabinoid receptor agonist methanandamide were injected 7 days to two groups of mice either at the doses of 2.5 mg/kg/day or 0,5 mg/kg/day. On the day 8 all mice were given a "challenge dose" of methamphetamine 2.5 mg/kg to check a development of the hypothesised sensitization. In Experiment 2, methamphetamine and combined methamphetamine+selective CB1 receptor antagonist AM 251 treatments were injected 7 days to two groups of mice at the doses of either 2.5 mg/kg/day or 5 mg/kg/day. For the same reason as in Experiment 1 "challenge doses" of methamphetamine 2.5 mg/kg were given to all mice on the day 8. In Experiment 1, it has been shown that compared to control animals this procedure elicited in both methamphetamine and methanandamide pre-treated groups behavioural sensitisation: significant increase in distance run and fast movements and a significant decrease in resting time. Conversely, in Experiment 2, while in the group
dcterms:title
Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour
skos:prefLabel
Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour
skos:notation
RIV/00216224:14110/03:00008969!RIV08-MSM-14110___
n4:strany
60 - 60
n4:aktivita
n8:Z
n4:aktivity
Z(MSM 141100001)
n4:cisloPeriodika
Suppl. 1
n4:dodaniDat
n14:2008
n4:domaciTvurceVysledku
n10:3007251 n10:3395197 n10:8841144
n4:druhVysledku
n13:J
n4:duvernostUdaju
n12:S
n4:entitaPredkladatele
n17:predkladatel
n4:idSjednocenehoVysledku
622817
n4:idVysledku
RIV/00216224:14110/03:00008969
n4:jazykVysledku
n18:eng
n4:klicovaSlova
Behavioural sensitization; AM 251; methamphetamine; methanandamide; locomotion; mice
n4:klicoveSlovo
n6:mice n6:methamphetamine n6:AM%20251 n6:locomotion n6:Behavioural%20sensitization n6:methanandamide
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[AB826AC26840]
n4:nazevZdroje
Behavioural Pharmacology
n4:obor
n15:FR
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
3
n4:rokUplatneniVysledku
n14:2003
n4:svazekPeriodika
14
n4:tvurceVysledku
Landa, Leoš Šlais, Karel Šulcová, Alexandra
n4:zamer
n5:MSM%20141100001
s:issn
0955-8810
s:numberOfPages
1
n7:organizacniJednotka
14110