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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F03%3A00008624%21RIV09-GA0-14110___
rdf:type
n3:Vysledek skos:Concept
dcterms:description
Components of the total ionic current responsible for rate-dependent changes of action potential (AP) configuration were analyzed by the AP clamp method in isolated rat ventricular myocytes. The results demonstrate that besides Ca2+-mediated currents, cumulative inactivation of the transient outward current Ito significantly participates on the rate-dependent variability of AP configuration. Under the effect of antiarrhythmic drug ajmaline (30mikromol/l), the fast sodium current INa causes marked changes in the repolarization phase of AP, very likely as a consequence of its use-dependent block. Byly analyzovány komponenty celkového iontového proudu zodpovědné za frekvenčně-závislé změny akčního napětí metodou vnuceného akčního napětí u izolovaných komorových srdečních buněk potkana. Components of the total ionic current responsible for rate-dependent changes of action potential (AP) configuration were analyzed by the AP clamp method in isolated rat ventricular myocytes. The results demonstrate that besides Ca2+-mediated currents, cumulative inactivation of the transient outward current Ito significantly participates on the rate-dependent variability of AP configuration. Under the effect of antiarrhythmic drug ajmaline (30mikromol/l), the fast sodium current INa causes marked changes in the repolarization phase of AP, very likely as a consequence of its use-dependent block.
dcterms:title
Rate dependent changes of action potential waveform in rat ventricular myocytes. Action potential voltage clamp experiments Rate dependent changes of action potential waveform in rat ventricular myocytes. Action potential voltage clamp experiments Rate dependent changes of action potential waveform in rat ventricular myocytes. Action potential voltage clamp experiments
skos:prefLabel
Rate dependent changes of action potential waveform in rat ventricular myocytes. Action potential voltage clamp experiments Rate dependent changes of action potential waveform in rat ventricular myocytes. Action potential voltage clamp experiments Rate dependent changes of action potential waveform in rat ventricular myocytes. Action potential voltage clamp experiments
skos:notation
RIV/00216224:14110/03:00008624!RIV09-GA0-14110___
n4:aktivita
n16:P n16:Z
n4:aktivity
P(GP204/02/D129), Z(MSM 141100004)
n4:dodaniDat
n20:2009
n4:domaciTvurceVysledku
n7:7773625 n7:1457160 n7:8165459 n7:7511671 n7:1722026
n4:druhVysledku
n11:B
n4:duvernostUdaju
n19:S
n4:entitaPredkladatele
n18:predkladatel
n4:idSjednocenehoVysledku
624597
n4:idVysledku
RIV/00216224:14110/03:00008624
n4:jazykVysledku
n12:eng
n4:klicovaSlova
rate dependence; action potential; action potential voltage clamp; rat; ajmaline
n4:klicoveSlovo
n15:action%20potential%20voltage%20clamp n15:rat n15:ajmaline n15:rate%20dependence n15:action%20potential
n4:kontrolniKodProRIV
[E8DD74A5619D]
n4:mistoVydani
Brno
n4:nazevEdiceCisloSvazku
neuveden
n4:nazevZdroje
Rate dependent changes of action potential waveform in rat ventricular myocytes. Action potential voltage clamp experiments
n4:obor
n13:ED
n4:pocetDomacichTvurcuVysledku
5
n4:pocetStranKnihy
7
n4:pocetTvurcuVysledku
5
n4:projekt
n10:GP204%2F02%2FD129
n4:rokUplatneniVysledku
n20:2003
n4:tvurceVysledku
Bébarová, Markéta Šimurdová, Milena Šimurda, Jiří Pásek, Michal Matejovič, Peter
n4:zamer
n21:MSM%20141100004
s:numberOfPages
7
n14:hasPublisher
Neuveden
n9:isbn
80-7013-394-5
n8:organizacniJednotka
14110