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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F02%3A00007141%21RIV08-MSM-14110___
rdf:type
n16:Vysledek skos:Concept
dcterms:description
To explore the effect of the cardiac transverse axial tubular system (TAT-system) on excitability of ventricular cells, we developed a quantitative model incorporating the function of the tubules. The model was based on a modified quantitative description proposed by Luo and Rudy (Circ Res, 1994;74:1071-96). The modifications are summarized in our previous publication (Pásek M. et al. Scripta Medica, 2002;75:179-86). The morphological parameters of the TAT-system were based on the study of Soeller and Cannel (Circ Res, 1999;84:266-75). The time constants of ionic diffusion between the TAT-system and external solution was set to 250 ms for Ca2+ ions and 63 ms for K+ and Na+ ions. The properties of the tubular and peripheral membrane were set according to recently published data. The results of simulations were strongly affected by incorporation of the TAT-system under the conditions of low external [K+]. The model including TAT-system began to produce early after-depolarizations at considerably lower v To explore the effect of the cardiac transverse axial tubular system (TAT-system) on excitability of ventricular cells, we developed a quantitative model incorporating the function of the tubules. The model was based on a modified quantitative description proposed by Luo and Rudy (Circ Res, 1994;74:1071-96). The modifications are summarized in our previous publication (Pásek M. et al. Scripta Medica, 2002;75:179-86). The morphological parameters of the TAT-system were based on the study of Soeller and Cannel (Circ Res, 1999;84:266-75). The time constants of ionic diffusion between the TAT-system and external solution was set to 250 ms for Ca2+ ions and 63 ms for K+ and Na+ ions. The properties of the tubular and peripheral membrane were set according to recently published data. The results of simulations were strongly affected by incorporation of the TAT-system under the conditions of low external [K+]. The model including TAT-system began to produce early after-depolarizations at considerably lower v To explore the effect of the cardiac transverse axial tubular system (TAT-system) on excitability of ventricular cells, we developed a quantitative model incorporating the function of the tubules. The model was based on a modified quantitative description proposed by Luo and Rudy (Circ Res, 1994;74:1071-96). The modifications are summarized in our previous publication (Pásek M. et al. Scripta Medica, 2002;75:179-86). The morphological parameters of the TAT-system were based on the study of Soeller and Cannel (Circ Res, 1999;84:266-75). The time constants of ionic diffusion between the TAT-system and external solution was set to 250 ms for Ca2+ ions and 63 ms for K+ and Na+ ions. The properties of the tubular and peripheral membrane were set according to recently published data. The results of simulations were strongly affected by incorporation of the TAT-system under the conditions of low external [K+]. The model including TAT-system began to produce early after-depolarizations at considerably lower v
dcterms:title
Role of TAT-system in cardiac excitability: investigation in a quantitative model of a ventricular cardiac cell Role of TAT-system in cardiac excitability: investigation in a quantitative model of a ventricular cardiac cell Role of TAT-system in cardiac excitability: investigation in a quantitative model of a ventricular cardiac cell
skos:prefLabel
Role of TAT-system in cardiac excitability: investigation in a quantitative model of a ventricular cardiac cell Role of TAT-system in cardiac excitability: investigation in a quantitative model of a ventricular cardiac cell Role of TAT-system in cardiac excitability: investigation in a quantitative model of a ventricular cardiac cell
skos:notation
RIV/00216224:14110/02:00007141!RIV08-MSM-14110___
n3:strany
47
n3:aktivita
n15:P n15:Z
n3:aktivity
P(GP204/02/D129), Z(MSM 141100004)
n3:dodaniDat
n5:2008
n3:domaciTvurceVysledku
n12:7511671 n12:7773625
n3:druhVysledku
n9:D
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
662663
n3:idVysledku
RIV/00216224:14110/02:00007141
n3:jazykVysledku
n8:eng
n3:klicovaSlova
cardiac cell; transverse-axial tubular system; quantitative modelling
n3:klicoveSlovo
n13:transverse-axial%20tubular%20system n13:cardiac%20cell n13:quantitative%20modelling
n3:kontrolniKodProRIV
[DDC173F4AFA5]
n3:mistoKonaniAkce
Smolenice
n3:mistoVydani
Smolenice
n3:nazevZdroje
New Frontiers in Basic Cardiovascular Research
n3:obor
n6:ED
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
3
n3:projekt
n18:GP204%2F02%2FD129
n3:rokUplatneniVysledku
n5:2002
n3:tvurceVysledku
Pásek, Michal Šimurda, Jiří Christé, Georges
n3:typAkce
n4:EUR
n3:zahajeniAkce
2002-01-01+01:00
n3:zamer
n21:MSM%20141100004
s:numberOfPages
1
n19:hasPublisher
Ústav molekulárnej fyziológie a genetiky SAV
n20:organizacniJednotka
14110