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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F02%3A00005822%21RIV08-GA0-14110___
rdf:type
n17:Vysledek skos:Concept
dcterms:description
We tested capabilities of drugs elevating extracellular adenosine and of granulocyte colony-stimulating, factor (G-CSF) given alone or in combination to modulate regeneration from severe myelosuppression resulting from combined exposure of mice to ionizing radiation and carboplatin. Elevation of extracellular adenosine was induced by joint administration of dipyridamole (DP), a drug inhibiting the cellular uptake of adenosine, and adenosine monophosphate (AMP), serving as an adenosine prodrug. DP+AMP, G-CSF or all these drugs in combination were administered in a 4-d treatment regimen starting on day 3 after induction of myelosuppression. Comparable enhancements of haematopoietic regeneration due to elevation of extracellular adenosine or to action of G-CSF were demonstrated as shown by elevated numbers of haematopoietic progenitor cells for granulocytes/macrophages (GM-CFC) and erythrocytes (BFU-E) in the bone marrow and spleen in early time intervals after termination of the drug treatment, i.e. on We tested capabilities of drugs elevating extracellular adenosine and of granulocyte colony-stimulating, factor (G-CSF) given alone or in combination to modulate regeneration from severe myelosuppression resulting from combined exposure of mice to ionizing radiation and carboplatin. Elevation of extracellular adenosine was induced by joint administration of dipyridamole (DP), a drug inhibiting the cellular uptake of adenosine, and adenosine monophosphate (AMP), serving as an adenosine prodrug. DP+AMP, G-CSF or all these drugs in combination were administered in a 4-d treatment regimen starting on day 3 after induction of myelosuppression. Comparable enhancements of haematopoietic regeneration due to elevation of extracellular adenosine or to action of G-CSF were demonstrated as shown by elevated numbers of haematopoietic progenitor cells for granulocytes/macrophages (GM-CFC) and erythrocytes (BFU-E) in the bone marrow and spleen in early time intervals after termination of the drug treatment, i.e. on We tested capabilities of drugs elevating extracellular adenosine and of granulocyte colony-stimulating, factor (G-CSF) given alone or in combination to modulate regeneration from severe myelosuppression resulting from combined exposure of mice to ionizing radiation and carboplatin. Elevation of extracellular adenosine was induced by joint administration of dipyridamole (DP), a drug inhibiting the cellular uptake of adenosine, and adenosine monophosphate (AMP), serving as an adenosine prodrug. DP+AMP, G-CSF or all these drugs in combination were administered in a 4-d treatment regimen starting on day 3 after induction of myelosuppression. Comparable enhancements of haematopoietic regeneration due to elevation of extracellular adenosine or to action of G-CSF were demonstrated as shown by elevated numbers of haematopoietic progenitor cells for granulocytes/macrophages (GM-CFC) and erythrocytes (BFU-E) in the bone marrow and spleen in early time intervals after termination of the drug treatment, i.e. on
dcterms:title
Drugs elevating extracellular adenosine promote regeneration of haematopoietic progenitor cells in severely myeloosuppressed mice: their comparison and joint effects with the granulocyte colony-stimulating factor Drugs elevating extracellular adenosine promote regeneration of haematopoietic progenitor cells in severely myeloosuppressed mice: their comparison and joint effects with the granulocyte colony-stimulating factor Drugs elevating extracellular adenosine promote regeneration of haematopoietic progenitor cells in severely myeloosuppressed mice: their comparison and joint effects with the granulocyte colony-stimulating factor
skos:prefLabel
Drugs elevating extracellular adenosine promote regeneration of haematopoietic progenitor cells in severely myeloosuppressed mice: their comparison and joint effects with the granulocyte colony-stimulating factor Drugs elevating extracellular adenosine promote regeneration of haematopoietic progenitor cells in severely myeloosuppressed mice: their comparison and joint effects with the granulocyte colony-stimulating factor Drugs elevating extracellular adenosine promote regeneration of haematopoietic progenitor cells in severely myeloosuppressed mice: their comparison and joint effects with the granulocyte colony-stimulating factor
skos:notation
RIV/00216224:14110/02:00005822!RIV08-GA0-14110___
n3:strany
4
n3:aktivita
n14:P
n3:aktivity
P(GA306/99/0027)
n3:cisloPeriodika
1
n3:dodaniDat
n6:2008
n3:domaciTvurceVysledku
n4:1647024 n4:3011518 n4:6661971 n4:8430322 n4:1730908 Pospíšil, Milan
n3:druhVysledku
n11:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
643705
n3:idVysledku
RIV/00216224:14110/02:00005822
n3:jazykVysledku
n12:eng
n3:klicovaSlova
extracellular adenosine; dipyridamole; adenosine monophosphate; G-CSF; ionizing radiation; cytostatic drugs; myelosuppression
n3:klicoveSlovo
n10:ionizing%20radiation n10:extracellular%20adenosine n10:G-CSF n10:dipyridamole n10:myelosuppression n10:adenosine%20monophosphate n10:cytostatic%20drugs
n3:kodStatuVydavatele
DK - Dánské království
n3:kontrolniKodProRIV
[C173EF3A337C]
n3:nazevZdroje
European Journal of Haematology
n3:obor
n13:FD
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
7
n3:projekt
n18:GA306%2F99%2F0027
n3:rokUplatneniVysledku
n6:2002
n3:svazekPeriodika
68
n3:tvurceVysledku
Hofer, Michal Pospíšil, Milan Holá, Jiřina Vácha, Jiří Znojil, Vladimír Vacek, Antonín Weiterová, Lenka
s:issn
0902-4441
s:numberOfPages
8
n7:organizacniJednotka
14110