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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F02%3A00005648%21RIV09-MSM-14110___
rdf:type
skos:Concept n16:Vysledek
dcterms:description
Zjistili jsme vyznamny rozdil mezi hladinami feritinu u zen diabeticek a nediabeticek. Alelicke frekvence obou studovanych SNP v HFE genu - C282Y a H63D - se nelisily mezi diabetiky a nediabetiky a rovnez hladiny feritinu u jednotlivych skupin podle nosicstvi mutaci v HFE genu nebyly statisticky vyznamne rozdilne. Aims of the study were: (i) to determine the prevalence of mutations C282Y and H63D in the HFE gene causing hereditary hemochromatosis in patients with type 2 diabetes mellitus and non-diabetics, (ii) to investigate the relationship among HFE genotypes, serum ferritin and glucose intolerance and (iii) to assess possible association of HFE mutations with the susceptibility to develop late diabetic complications in the Czech population. Two approaches were employed - the case-control study comprising diabetics and non-diabetic controls (n=326) and the cross-sectional study comprising subjects with a previously unknown defect in glucose tolerance (n=113, oral glucose tolerance test performed in each subject). Allele frequencies of C282Y and H63D did not differ between diabetic and control groups nor among subjects with normal glucose tolerance (NGT), impaired glucose tolerance (IGT) and diabetes. Ferritin levels significantly differed between diabetic and non-diabetic women (P<1.10-3) and among subjec Aims of the study were: (i) to determine the prevalence of mutations C282Y and H63D in the HFE gene causing hereditary hemochromatosis in patients with type 2 diabetes mellitus and non-diabetics, (ii) to investigate the relationship among HFE genotypes, serum ferritin and glucose intolerance and (iii) to assess possible association of HFE mutations with the susceptibility to develop late diabetic complications in the Czech population. Two approaches were employed - the case-control study comprising diabetics and non-diabetic controls (n=326) and the cross-sectional study comprising subjects with a previously unknown defect in glucose tolerance (n=113, oral glucose tolerance test performed in each subject). Allele frequencies of C282Y and H63D did not differ between diabetic and control groups nor among subjects with normal glucose tolerance (NGT), impaired glucose tolerance (IGT) and diabetes. Ferritin levels significantly differed between diabetic and non-diabetic women (P<1.10-3) and among subjec
dcterms:title
Relations among serum ferritin, C282Y and H63D mutations in the HFE gene and type 2 diabetes mellitus in the Czech population Relations among serum ferritin, C282Y and H63D mutations in the HFE gene and type 2 diabetes mellitus in the Czech population Vztah mezi serovym feritinem, mutacemi C282Y a H63D v HFE genu a diabetem typu 2 v Ceske populaci
skos:prefLabel
Vztah mezi serovym feritinem, mutacemi C282Y a H63D v HFE genu a diabetem typu 2 v Ceske populaci Relations among serum ferritin, C282Y and H63D mutations in the HFE gene and type 2 diabetes mellitus in the Czech population Relations among serum ferritin, C282Y and H63D mutations in the HFE gene and type 2 diabetes mellitus in the Czech population
skos:notation
RIV/00216224:14110/02:00005648!RIV09-MSM-14110___
n3:aktivita
n18:Z
n3:aktivity
Z(MSM 141100002)
n3:cisloPeriodika
5
n3:dodaniDat
n6:2009
n3:domaciTvurceVysledku
n4:8780757 n4:2529947 n4:1730908 n4:1192833 n4:7988788 n4:4592026
n3:druhVysledku
n7:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
661975
n3:idVysledku
RIV/00216224:14110/02:00005648
n3:jazykVysledku
n14:eng
n3:klicovaSlova
ferritin; HFE gene; type 2 diabetes mellitus
n3:klicoveSlovo
n8:HFE%20gene n8:ferritin n8:type%202%20diabetes%20mellitus
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[3DFAC3FD3CCB]
n3:nazevZdroje
Experimental and Clinical Endocrinology & Diabetes
n3:obor
n12:FB
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
7
n3:rokUplatneniVysledku
n6:2002
n3:svazekPeriodika
110
n3:tvurceVysledku
Márová, Ivana Vácha, Jiří Kaňková, Kateřina Pácal, Lukáš Jansen, Eugene HJM Stejskalová, Andrea Mužík, Jan
n3:wos
000177344600004
n3:zamer
n11:MSM%20141100002
s:issn
0947-7349
s:numberOfPages
7
n15:organizacniJednotka
14110