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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F01%3A00030461%21RIV10-MSM-14110___
rdf:type
n12:Vysledek skos:Concept
dcterms:description
We examined major histocompatibility complex (MHC) class II expression in B cells, peripheral blood monocytes, activated T cells, epidermal Langerhans cells, monocyte-derived dendritic cells, dermal microvascular endothelial cells (DMEC) and fibroblasts of twin brothers with MHC class II deficiency. Although residual human leucocyte antigen (HLA)-DR expression was found on a subpopulation of epidermal Langerhans cells and a subset of peripheral blood monocyte-derived dendritic cells, the patients' B cells, monocytes and activated T cells were HLA-DR negative. After treatment with interferon-gamma (IFN-gamma), the patients' DMEC expressed HLA-DR but not -DP and -DQ at the protein and mRNA level, whereas IFN-gamma failed to induce HLA-DR expression on dermal fibroblasts. We examined major histocompatibility complex (MHC) class II expression in B cells, peripheral blood monocytes, activated T cells, epidermal Langerhans cells, monocyte-derived dendritic cells, dermal microvascular endothelial cells (DMEC) and fibroblasts of twin brothers with MHC class II deficiency. Although residual human leucocyte antigen (HLA)-DR expression was found on a subpopulation of epidermal Langerhans cells and a subset of peripheral blood monocyte-derived dendritic cells, the patients' B cells, monocytes and activated T cells were HLA-DR negative. After treatment with interferon-gamma (IFN-gamma), the patients' DMEC expressed HLA-DR but not -DP and -DQ at the protein and mRNA level, whereas IFN-gamma failed to induce HLA-DR expression on dermal fibroblasts.
dcterms:title
Residual expression of functional MHC class II molecules in twin brothers with MHC class II deficiency is cell type specific Residual expression of functional MHC class II molecules in twin brothers with MHC class II deficiency is cell type specific
skos:prefLabel
Residual expression of functional MHC class II molecules in twin brothers with MHC class II deficiency is cell type specific Residual expression of functional MHC class II molecules in twin brothers with MHC class II deficiency is cell type specific
skos:notation
RIV/00216224:14110/01:00030461!RIV10-MSM-14110___
n3:aktivita
n13:S
n3:aktivity
S
n3:cisloPeriodika
2
n3:dodaniDat
n10:2010
n3:domaciTvurceVysledku
n16:3198391
n3:druhVysledku
n15:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n5:predkladatel
n3:idSjednocenehoVysledku
694596
n3:idVysledku
RIV/00216224:14110/01:00030461
n3:jazykVysledku
n6:eng
n3:klicovaSlova
MHC class II deficiency; dendritic cells; endothelial cells; antigen presentation; residual cell type-specific MHC class II expression
n3:klicoveSlovo
n11:dendritic%20cells n11:MHC%20class%20II%20deficiency n11:antigen%20presentation n11:endothelial%20cells n11:residual%20cell%20type-specific%20MHC%20class%20II%20expression
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[9EE496495AB1]
n3:nazevZdroje
British Journal of Haematology
n3:obor
n7:EC
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
5
n3:rokUplatneniVysledku
n10:2001
n3:svazekPeriodika
115
n3:tvurceVysledku
Wolf, H. M. Eibl, Marta Petzelbauer, P. Lechleitner, S. Thon, Vojtěch
n3:wos
000172403300036
s:issn
0007-1048
s:numberOfPages
12
n9:organizacniJednotka
14110