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Statements

Subject Item
n2:RIV%2F00216208%3A11510%2F13%3A10191538%21RIV14-MSM-11510___
rdf:type
n5:Vysledek skos:Concept
rdfs:seeAlso
http://www.biomed.cas.cz/physiolres/pdf/62/62_721.pdf
dcterms:description
Creatine (Cr) is recommended as a dietary supplement especially for athletes but its therapeutic potential is also discussed. It is assumed that human body uses Cr for the formation of phosphocreatine, which is necessary for muscular work as a source of energy. Production of Cr in a body is closely connected to methionine cycle where guanidinoacetate (GAA) is in a final step methylated from S-adenosylmethionine (SAM). Increased availability of SAM for phosphatidylcholine (PC) and sarcosine synthesis can potentially stimulate endogenous production of betaine a thus methylation of homocysteine (HCy) to form methionine. Our subject who was methylenetetrahydrofolate reductase (MTHFR) 677TT homozygote lowered plasma HCy from 33.3 micromol/l to 17.1 micromol/l following one-month Cr supplementation (5 g/day) opposite to 677CC and CT genotypes whose HCy levels tended to increase (but still in normal ranges). We suppose that Cr supplementation stimulates pathways leading to production of sarcosine which can serve to regenerate tetrahydrofolate (THF) to form 5,10-methylene-THF. This could potentially increase MTHFR enzyme activity which may later result in increased HCy methylation. Cr supplementation significantly effects metabolism of one carbon unit and potentially lower body s demands for methyl groups. This could be beneficial as in the case of reduced enzyme activity such as MTHFR 677C/T polymorphism. Creatine (Cr) is recommended as a dietary supplement especially for athletes but its therapeutic potential is also discussed. It is assumed that human body uses Cr for the formation of phosphocreatine, which is necessary for muscular work as a source of energy. Production of Cr in a body is closely connected to methionine cycle where guanidinoacetate (GAA) is in a final step methylated from S-adenosylmethionine (SAM). Increased availability of SAM for phosphatidylcholine (PC) and sarcosine synthesis can potentially stimulate endogenous production of betaine a thus methylation of homocysteine (HCy) to form methionine. Our subject who was methylenetetrahydrofolate reductase (MTHFR) 677TT homozygote lowered plasma HCy from 33.3 micromol/l to 17.1 micromol/l following one-month Cr supplementation (5 g/day) opposite to 677CC and CT genotypes whose HCy levels tended to increase (but still in normal ranges). We suppose that Cr supplementation stimulates pathways leading to production of sarcosine which can serve to regenerate tetrahydrofolate (THF) to form 5,10-methylene-THF. This could potentially increase MTHFR enzyme activity which may later result in increased HCy methylation. Cr supplementation significantly effects metabolism of one carbon unit and potentially lower body s demands for methyl groups. This could be beneficial as in the case of reduced enzyme activity such as MTHFR 677C/T polymorphism.
dcterms:title
Effect of the MTHFR 677C/T polymorphism on homocysteinemia in response to creatine supplementation: a case study Effect of the MTHFR 677C/T polymorphism on homocysteinemia in response to creatine supplementation: a case study
skos:prefLabel
Effect of the MTHFR 677C/T polymorphism on homocysteinemia in response to creatine supplementation: a case study Effect of the MTHFR 677C/T polymorphism on homocysteinemia in response to creatine supplementation: a case study
skos:notation
RIV/00216208:11510/13:10191538!RIV14-MSM-11510___
n5:predkladatel
n8:orjk%3A11510
n3:aktivita
n19:Z n19:S n19:I
n3:aktivity
I, S, Z(MSM0021620864)
n3:cisloPeriodika
6
n3:dodaniDat
n17:2014
n3:domaciTvurceVysledku
n13:5432200 n13:8399689 n13:9106278
n3:druhVysledku
n7:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
71797
n3:idVysledku
RIV/00216208:11510/13:10191538
n3:jazykVysledku
n12:eng
n3:klicovaSlova
677C/T; MTHFR gene; Supplementation; Homocysteine (HCy); Creatine (Cr)
n3:klicoveSlovo
n9:Supplementation n9:MTHFR%20gene n9:Homocysteine%20%28HCy%29 n9:Creatine%20%28Cr%29 n9:677C%2FT
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[5A2F197E6799]
n3:nazevZdroje
Physiological Research
n3:obor
n6:EB
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:rokUplatneniVysledku
n17:2013
n3:svazekPeriodika
62
n3:tvurceVysledku
Kohlíková, Eva Petr, Miroslav Šteffl, Michal
n3:wos
000329167600014
n3:zamer
n18:MSM0021620864
s:issn
0862-8408
s:numberOfPages
9
n14:organizacniJednotka
11510