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Statements

Subject Item
n2:RIV%2F00216208%3A11410%2F13%3A10193340%21RIV15-MSM-11410___
rdf:type
n11:Vysledek skos:Concept
rdfs:seeAlso
http://fb.cuni.cz/file/5706/FB2013A0033.pdf
dcterms:description
Haem oxygenase 1 (HO-1) plays a pivotal role in metabolic stress protecting cells in dependence on reactive oxygen species. This study investigated a potential gene environment interaction between the (GT)n repeat HO1 polymorphism and the stress perception in patients with eating disorder and in controls. Stress perception and (GT)n polymorphism were measured in 127 patients with eating disorders and in 78 healthy controls using Stress and Coping Inventory and genotyping. Based on the inventory, overall, specific and weighted stress scores were defined. Clinical stress score was generated according to the patient's history and interviews. According to our hypothesis, 1) all stress scores describing subjective stress perception were significantly higher in patients compared to controls (P LESS-THAN OR EQUAL TO 0.001; P LESS-THAN OR EQUAL TO 0.002; P LESS-THAN OR EQUAL TO 0.001), 2) the L/L genotype of GT promoter repeats (L < 25 GT repeats, S < 25 GT repeats) in the patients was associated with higher overall (P LESS-THAN OR EQUAL TO 0.001), specific (P LESS-THAN OR EQUAL TO 0.010) and weighted stress score (P LESS-THAN OR EQUAL TO 0.005) compared to the L/S variant, and 3) Pearson's correlation of clinical versus objective stress scores showed not very tight relationship (0.198; 0.287; 0.224, respectively). We assume potential risk of the L allele of HO1 promoter polymorphism for the stress response and contribution of the subjective stress perception together with the L/L genotype to the development of eating disorder. Decreased HO1 expression in the presence of L/L genotype plus more intensive stress perception in the patients can lead to secondary stress, with increasing severity of the symptoms and aggravation of the disease. Haem oxygenase 1 (HO-1) plays a pivotal role in metabolic stress protecting cells in dependence on reactive oxygen species. This study investigated a potential gene environment interaction between the (GT)n repeat HO1 polymorphism and the stress perception in patients with eating disorder and in controls. Stress perception and (GT)n polymorphism were measured in 127 patients with eating disorders and in 78 healthy controls using Stress and Coping Inventory and genotyping. Based on the inventory, overall, specific and weighted stress scores were defined. Clinical stress score was generated according to the patient's history and interviews. According to our hypothesis, 1) all stress scores describing subjective stress perception were significantly higher in patients compared to controls (P LESS-THAN OR EQUAL TO 0.001; P LESS-THAN OR EQUAL TO 0.002; P LESS-THAN OR EQUAL TO 0.001), 2) the L/L genotype of GT promoter repeats (L < 25 GT repeats, S < 25 GT repeats) in the patients was associated with higher overall (P LESS-THAN OR EQUAL TO 0.001), specific (P LESS-THAN OR EQUAL TO 0.010) and weighted stress score (P LESS-THAN OR EQUAL TO 0.005) compared to the L/S variant, and 3) Pearson's correlation of clinical versus objective stress scores showed not very tight relationship (0.198; 0.287; 0.224, respectively). We assume potential risk of the L allele of HO1 promoter polymorphism for the stress response and contribution of the subjective stress perception together with the L/L genotype to the development of eating disorder. Decreased HO1 expression in the presence of L/L genotype plus more intensive stress perception in the patients can lead to secondary stress, with increasing severity of the symptoms and aggravation of the disease.
dcterms:title
Stress Perception and (GT)n Repeat Polymorphism in Haem Oxygenase 1 Promoter Are Both Risk Factors in Development of Eating Disorders Stress Perception and (GT)n Repeat Polymorphism in Haem Oxygenase 1 Promoter Are Both Risk Factors in Development of Eating Disorders
skos:prefLabel
Stress Perception and (GT)n Repeat Polymorphism in Haem Oxygenase 1 Promoter Are Both Risk Factors in Development of Eating Disorders Stress Perception and (GT)n Repeat Polymorphism in Haem Oxygenase 1 Promoter Are Both Risk Factors in Development of Eating Disorders
skos:notation
RIV/00216208:11410/13:10193340!RIV15-MSM-11410___
n4:aktivita
n6:Z n6:I n6:P
n4:aktivity
I, P(NT14094), Z(MSM0021620849)
n4:cisloPeriodika
6
n4:dodaniDat
n10:2015
n4:domaciTvurceVysledku
n9:3418650
n4:druhVysledku
n20:J
n4:duvernostUdaju
n5:S
n4:entitaPredkladatele
n14:predkladatel
n4:idSjednocenehoVysledku
108236
n4:idVysledku
RIV/00216208:11410/13:10193340
n4:jazykVysledku
n18:eng
n4:klicovaSlova
development; disorders; eating; factors; risk; both; are; gene; HO-1; polymorphism; repeat; GTn; perception; Stress
n4:klicoveSlovo
n8:eating n8:risk n8:both n8:HO-1 n8:are n8:GTn n8:disorders n8:repeat n8:Stress n8:gene n8:polymorphism n8:factors n8:development n8:perception
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[9D48EE7F249F]
n4:nazevZdroje
Folia Biologica
n4:obor
n19:FL
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
6
n4:projekt
n17:NT14094
n4:rokUplatneniVysledku
n10:2013
n4:svazekPeriodika
59
n4:tvurceVysledku
Chvál, Martin Kaminská, Deborah Šlachtová, Lenka Papežová, Hana Králík, Lubomír Martásek, Pavel
n4:wos
000330161600004
n4:zamer
n12:MSM0021620849
s:issn
0015-5500
s:numberOfPages
7
n7:organizacniJednotka
11410