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Statements

Subject Item
n2:RIV%2F00216208%3A11320%2F14%3A10283120%21RIV15-MSM-11320___
rdf:type
skos:Concept n17:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1016/j.febslet.2013.11.038
dcterms:description
We report sphingolipid-related reorganization of gel-like microdomains in the plasma membrane of living Saccharomyces cerevisiae using trans-Parinaric acid (t-PnA) and 1,6-diphenyl-1,3,5-hexatriene (DPH). Compared to control, the gel-like domains were significantly reduced in the membrane of a sphingolipid-deficient lcb1-100 mutant. The same reduction resulted from sphingolipid depletion by myriocin. The phenotype could be reverted when a myriocin-induced block in sphingolipid biosynthesis was bypassed by exogenous dihydrosphingosine. Lipid order of less-ordered membrane regions decreased with sphingolipid depletion as well, as documented by DPH fluorescence anisotropy. The data indicate that organization of lateral microdomains is an essential physiological role of these structural lipids. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. We report sphingolipid-related reorganization of gel-like microdomains in the plasma membrane of living Saccharomyces cerevisiae using trans-Parinaric acid (t-PnA) and 1,6-diphenyl-1,3,5-hexatriene (DPH). Compared to control, the gel-like domains were significantly reduced in the membrane of a sphingolipid-deficient lcb1-100 mutant. The same reduction resulted from sphingolipid depletion by myriocin. The phenotype could be reverted when a myriocin-induced block in sphingolipid biosynthesis was bypassed by exogenous dihydrosphingosine. Lipid order of less-ordered membrane regions decreased with sphingolipid depletion as well, as documented by DPH fluorescence anisotropy. The data indicate that organization of lateral microdomains is an essential physiological role of these structural lipids. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
dcterms:title
Sphingolipid levels crucially modulate lateral microdomain organization of plasma membrane in living yeast Sphingolipid levels crucially modulate lateral microdomain organization of plasma membrane in living yeast
skos:prefLabel
Sphingolipid levels crucially modulate lateral microdomain organization of plasma membrane in living yeast Sphingolipid levels crucially modulate lateral microdomain organization of plasma membrane in living yeast
skos:notation
RIV/00216208:11320/14:10283120!RIV15-MSM-11320___
n3:aktivita
n14:I n14:P
n3:aktivity
I, P(GAP205/12/0720)
n3:cisloPeriodika
3
n3:dodaniDat
n9:2015
n3:domaciTvurceVysledku
n6:7948395 n6:2436191
n3:druhVysledku
n18:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
46626
n3:idVysledku
RIV/00216208:11320/14:10283120
n3:jazykVysledku
n5:eng
n3:klicovaSlova
Time-resolved fluorescence; Fluorescence anisotropy; Fluidity; Lipid order; Membrane microdomain
n3:klicoveSlovo
n4:Time-resolved%20fluorescence n4:Membrane%20microdomain n4:Fluorescence%20anisotropy n4:Fluidity n4:Lipid%20order
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[A17134E641C7]
n3:nazevZdroje
FEBS Letters
n3:obor
n15:BO
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
4
n3:projekt
n13:GAP205%2F12%2F0720
n3:rokUplatneniVysledku
n9:2014
n3:svazekPeriodika
588
n3:tvurceVysledku
Heřman, Petr Malinsky, Jan Večeř, Jaroslav Vesela, Petra
n3:wos
000329976800010
s:issn
0014-5793
s:numberOfPages
7
n20:doi
10.1016/j.febslet.2013.11.038
n16:organizacniJednotka
11320