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Statements

Subject Item
n2:RIV%2F00216208%3A11320%2F07%3A00004673%21RIV08-MSM-11320___
rdf:type
skos:Concept n11:Vysledek
dcterms:description
NADH:ubichinon oxidoreduktáza či komplex I mitochondriálního dýchacího řetězce je složitý enzym s životně důležitou rolí v energetickém metabolismu. Dříve jsme vyvinuli hlístový model komplexu I spojený s mitochondriální dysfunkcí, jejíž rysy jsou charakteristické pro mitochondriální onemocnění jako je mléčná acidóza a snížené dýchání. Exprimovali jsme gen NDI1 ze Saccharomyces cerevisiae, v druhu Caenorhabditis elegans s poškozeným komplexem I. The NADH:ubiquinone oxidoreductase or complex I of the mitochondrial respiratory chain is an intricate enzyme with a vital role in energy metabolism. We have previously developed a nematode model of complex I-associated mitochondrial dysfunction that features hallmark characteristics of mitochondrial disease, such as lactic acidosis and decreased respiration. We have expressed the Saccharomyces cerevisiae NDI1 gene in a strain of Caenorhabditis elegans with an impaired complex I. Expression of Ndi1p produces marked improvements in animal fitness and reproduction, increases respiration rates and restores mitochondrial membrane potential to wild type levels. Ndi1p functionally integrates into the nematode respiratory chain and mitigates the deleterious effects of a complex I deficit. However, we have also shown that Ndi1p cannot substitute for the absence of complex I. Nevertheless, the yeast Ndi1p should be considered as a candidate for gene therapy in human diseases involving complex I. The NADH:ubiquinone oxidoreductase or complex I of the mitochondrial respiratory chain is an intricate enzyme with a vital role in energy metabolism. We have previously developed a nematode model of complex I-associated mitochondrial dysfunction that features hallmark characteristics of mitochondrial disease, such as lactic acidosis and decreased respiration. We have expressed the Saccharomyces cerevisiae NDI1 gene in a strain of Caenorhabditis elegans with an impaired complex I. Expression of Ndi1p produces marked improvements in animal fitness and reproduction, increases respiration rates and restores mitochondrial membrane potential to wild type levels. Ndi1p functionally integrates into the nematode respiratory chain and mitigates the deleterious effects of a complex I deficit. However, we have also shown that Ndi1p cannot substitute for the absence of complex I. Nevertheless, the yeast Ndi1p should be considered as a candidate for gene therapy in human diseases involving complex I.
dcterms:title
Expression of Ndi1p, an alternative NADH:ubiquinone oxidoreductase, increases mitochondrial membrane potential in a C. elegans model of mitochondrial disease Expression of Ndi1p, an alternative NADH:ubiquinone oxidoreductase, increases mitochondrial membrane potential in a C. elegans model of mitochondrial disease Exprese proteinu Ndi1, alternativní NADH:ubichinon oxidoreduktázy, zvyšuje mitochondriální membránový potenciál v C. elegans, modelového organismu pro mitochondriální onemocnění
skos:prefLabel
Exprese proteinu Ndi1, alternativní NADH:ubichinon oxidoreduktázy, zvyšuje mitochondriální membránový potenciál v C. elegans, modelového organismu pro mitochondriální onemocnění Expression of Ndi1p, an alternative NADH:ubiquinone oxidoreductase, increases mitochondrial membrane potential in a C. elegans model of mitochondrial disease Expression of Ndi1p, an alternative NADH:ubiquinone oxidoreductase, increases mitochondrial membrane potential in a C. elegans model of mitochondrial disease
skos:notation
RIV/00216208:11320/07:00004673!RIV08-MSM-11320___
n4:strany
1157;1163
n4:aktivita
n17:Z
n4:aktivity
Z(MSM0021620835)
n4:cisloPeriodika
9
n4:dodaniDat
n7:2008
n4:domaciTvurceVysledku
n15:6216277
n4:druhVysledku
n9:J
n4:duvernostUdaju
n16:S
n4:entitaPredkladatele
n18:predkladatel
n4:idSjednocenehoVysledku
421417
n4:idVysledku
RIV/00216208:11320/07:00004673
n4:jazykVysledku
n10:eng
n4:klicovaSlova
Expression; Ndi1p; alternative; ubiquinone; oxidoreductase; increases; mitochondrial; membrane; potential; elegans; model; mitochondrial; disease
n4:klicoveSlovo
n5:potential n5:disease n5:Ndi1p n5:increases n5:membrane n5:oxidoreductase n5:elegans n5:Expression n5:mitochondrial n5:model n5:ubiquinone n5:alternative
n4:kodStatuVydavatele
NL - Nizozemsko
n4:kontrolniKodProRIV
[2A97BE825364]
n4:nazevZdroje
Biochimica et Biophysica Acta - Bioenergetics
n4:obor
n13:BO
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
4
n4:rokUplatneniVysledku
n7:2007
n4:svazekPeriodika
1767
n4:tvurceVysledku
Gášková, Dana
n4:zamer
n12:MSM0021620835
s:issn
0005-2728
s:numberOfPages
7
n8:organizacniJednotka
11320