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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F14%3A10289123%21RIV15-MSM-11310___
rdf:type
n4:Vysledek skos:Concept
dcterms:description
Physicochemical interactions between the cell and its environment are crucial for morphogenesis, tissue homeostasis, remodeling and pathogenesis. Cells form specialized structures like focal adhesions and podosomes that are responsible for bi-directional information exchange between the cell and its surroundings. Besides their role in the transmission of regulatory signals, these structures are also involved in mechanosensing and mechanotransduction. In the past few years, many research groups have been trying to elucidate the mechanisms and consequences of the mechanosensitivity of cells. In this review we discuss the role of the integrin pathway in cellular mechanosensing, focusing on primary mechanosensors, molecules that respond to mechanical stress by changing their conformation. We propose mechanisms by which p130Cas is involved in this process, and emphasize the importance of mechanosensing in cell physiology and the development of diseases. (C) 2014 The Authors. Published by Elsevier GmbH. Physicochemical interactions between the cell and its environment are crucial for morphogenesis, tissue homeostasis, remodeling and pathogenesis. Cells form specialized structures like focal adhesions and podosomes that are responsible for bi-directional information exchange between the cell and its surroundings. Besides their role in the transmission of regulatory signals, these structures are also involved in mechanosensing and mechanotransduction. In the past few years, many research groups have been trying to elucidate the mechanisms and consequences of the mechanosensitivity of cells. In this review we discuss the role of the integrin pathway in cellular mechanosensing, focusing on primary mechanosensors, molecules that respond to mechanical stress by changing their conformation. We propose mechanisms by which p130Cas is involved in this process, and emphasize the importance of mechanosensing in cell physiology and the development of diseases. (C) 2014 The Authors. Published by Elsevier GmbH.
dcterms:title
Mechanosensors in integrin signaling: The emerging role of p130Cas Mechanosensors in integrin signaling: The emerging role of p130Cas
skos:prefLabel
Mechanosensors in integrin signaling: The emerging role of p130Cas Mechanosensors in integrin signaling: The emerging role of p130Cas
skos:notation
RIV/00216208:11310/14:10289123!RIV15-MSM-11310___
n6:aktivita
n14:I n14:P
n6:aktivity
I, P(EE2.3.30.0061), P(GC13-24851J)
n6:cisloPeriodika
10-12
n6:dodaniDat
n10:2015
n6:domaciTvurceVysledku
n7:3708608 Pataki, Andreea Csilla n7:5731534 n7:3950441
n6:druhVysledku
n17:J
n6:duvernostUdaju
n12:S
n6:entitaPredkladatele
n9:predkladatel
n6:idSjednocenehoVysledku
28161
n6:idVysledku
RIV/00216208:11310/14:10289123
n6:jazykVysledku
n18:eng
n6:klicovaSlova
p130Cas; Integrins; Podosomes; Focal adhesions; Mechanosensing
n6:klicoveSlovo
n11:Podosomes n11:p130Cas n11:Mechanosensing n11:Integrins n11:Focal%20adhesions
n6:kodStatuVydavatele
DE - Spolková republika Německo
n6:kontrolniKodProRIV
[1F52C7310F6E]
n6:nazevZdroje
European Journal of Cell Biology
n6:obor
n16:EB
n6:pocetDomacichTvurcuVysledku
4
n6:pocetTvurcuVysledku
4
n6:projekt
n8:EE2.3.30.0061 n8:GC13-24851J
n6:rokUplatneniVysledku
n10:2014
n6:svazekPeriodika
93
n6:tvurceVysledku
Pataki, Andreea Csilla Rösel, Daniel Janoštiak, Radoslav Brábek, Jan
n6:wos
000347271800009
s:issn
0171-9335
s:numberOfPages
10
n15:organizacniJednotka
11310