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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F14%3A10289031%21RIV15-MSM-11310___
rdf:type
n9:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1186/1758-5996-6-100
dcterms:description
Background: Adolescence, due to transient pubertal insulin resistance (IR), is associated with a higher risk for disturbances of glucose metabolism. The aim of our study was 1) to investigate the prevalence of disturbances of glucose metabolism, 2) to define gender specific homeostasis model assessment of insulin resistance (HOMA-IR) thresholds associated with increased cardiometabolic risks and 3) to provide predictors of HOMA-IR. Methods: The studied cohort consisted of Czech adolescents aged 13.0-17.9 years: 1,518 individuals of general population and three studied groups according weight category (615 normal weight, 230 overweight and 683 obese). The prevalence of IR, impaired fasting glucose (IFG) and type 2 diabetes was assessed. Risky HOMA-IR thresholds based on components of metabolic syndrome were investigated. HOMA-IR prediction was calculated taking into account age, blood pressure, multiple anthropometric, biochemical and hormonal parameters. Results: In general population cohort, the prevalence of IFG and type 2 diabetes was 7.0% and <0.5%, respectively. Boys regardless of weight presented significantly higher levels of blood glucose and higher prevalence of IFG than girls. Obese boys were found more insulin resistant than obese girls. HOMA-IR thresholds of 3.6 for girls and 4.4 for boys were associated with increased cardiometabolic risks. For both genders, the model of HOMA-IR prediction was composed of age, BMI, ratio of free triiodthyronine to free thyroxine, gamma-glutamyltransferase activity and levels of triglycerides and sex hormone-binding globulin. Conclusions: The type 2 diabetes in adolescents, including those who were obese, was rarely diagnosed. Obese adolescent boys were at greater risk for IR and for IFG than obese girls. In adolescence, thresholds of HOMA-IR in contrast to predictors were found gender specific. Background: Adolescence, due to transient pubertal insulin resistance (IR), is associated with a higher risk for disturbances of glucose metabolism. The aim of our study was 1) to investigate the prevalence of disturbances of glucose metabolism, 2) to define gender specific homeostasis model assessment of insulin resistance (HOMA-IR) thresholds associated with increased cardiometabolic risks and 3) to provide predictors of HOMA-IR. Methods: The studied cohort consisted of Czech adolescents aged 13.0-17.9 years: 1,518 individuals of general population and three studied groups according weight category (615 normal weight, 230 overweight and 683 obese). The prevalence of IR, impaired fasting glucose (IFG) and type 2 diabetes was assessed. Risky HOMA-IR thresholds based on components of metabolic syndrome were investigated. HOMA-IR prediction was calculated taking into account age, blood pressure, multiple anthropometric, biochemical and hormonal parameters. Results: In general population cohort, the prevalence of IFG and type 2 diabetes was 7.0% and <0.5%, respectively. Boys regardless of weight presented significantly higher levels of blood glucose and higher prevalence of IFG than girls. Obese boys were found more insulin resistant than obese girls. HOMA-IR thresholds of 3.6 for girls and 4.4 for boys were associated with increased cardiometabolic risks. For both genders, the model of HOMA-IR prediction was composed of age, BMI, ratio of free triiodthyronine to free thyroxine, gamma-glutamyltransferase activity and levels of triglycerides and sex hormone-binding globulin. Conclusions: The type 2 diabetes in adolescents, including those who were obese, was rarely diagnosed. Obese adolescent boys were at greater risk for IR and for IFG than obese girls. In adolescence, thresholds of HOMA-IR in contrast to predictors were found gender specific.
dcterms:title
Glucose homeostasis and insulin resistance: prevalence, gender differences and predictors in adolescents Glucose homeostasis and insulin resistance: prevalence, gender differences and predictors in adolescents
skos:prefLabel
Glucose homeostasis and insulin resistance: prevalence, gender differences and predictors in adolescents Glucose homeostasis and insulin resistance: prevalence, gender differences and predictors in adolescents
skos:notation
RIV/00216208:11310/14:10289031!RIV15-MSM-11310___
n4:aktivita
n5:I n5:S
n4:aktivity
I, S
n4:cisloPeriodika
September 2014
n4:dodaniDat
n12:2015
n4:domaciTvurceVysledku
n8:3002497 n8:8937842
n4:druhVysledku
n10:J
n4:duvernostUdaju
n13:S
n4:entitaPredkladatele
n11:predkladatel
n4:idSjednocenehoVysledku
18441
n4:idVysledku
RIV/00216208:11310/14:10289031
n4:jazykVysledku
n19:eng
n4:klicovaSlova
Type 2 diabetes; Obesity; Metabolic syndrome; Insulin resistance; HOMA-IR prediction; Glucose homeostasis; Adolescence
n4:klicoveSlovo
n7:Metabolic%20syndrome n7:Insulin%20resistance n7:Obesity n7:Adolescence n7:HOMA-IR%20prediction n7:Type%202%20diabetes n7:Glucose%20homeostasis
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[56655AAC47E0]
n4:nazevZdroje
Diabetology and Metabolic Syndrome
n4:obor
n18:FB
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
9
n4:rokUplatneniVysledku
n12:2014
n4:svazekPeriodika
6
n4:tvurceVysledku
Hainer, Vojtěch Aldhoon-Hainerová, Irena Dušátková, Lenka Hampl, Richard Sedláčková, Barbora Kunešová, Marie Hill, Martin Hlavatý, Petr Zamrazilová, Hana
n4:wos
000343774500001
s:issn
1758-5996
s:numberOfPages
9
n16:doi
10.1186/1758-5996-6-100
n15:organizacniJednotka
11310